Doris Taylor, Ph.D.

dataylor@umn.edu

Education

B.S., Biology, Mississippi University for Women, Columbus, MS, 1977
Ph.D., Pharmacology, Southwestern Medical School, Dallas, TX, 1988

Research Interests

As the Medtronic-Bakken Chair in Cardiac Repair and the Director of the Center for Cardiovascular Repair, Dr. Taylor blends research using stem cells, genes, and devices to develop novel cardiac and vascular technologies--ones to prevent, treat, and hopefully one day, cure heart ailments.  She is involved in both laboratory and clinical studies using cell therapy to treat disease.

Creating a New Heart in the Lab

Click on the video below to see the amazing results of technology!

Selected Publications

• Taylor DA, Atkins BZ, Hungspreugs P, Jones TR, Reedy MC, Hutcheson KA, Glower DD,  Kraus WE. (1998) Regenerating Functional Myocardium:  Improved Performance after Skeletal Myoblast Transplantation; Nat Med. Aug;4(8):929-33. Erratum in: Nat Med. Oct;4(10):1200.

• Dai Q, Thompson MA, Pippen AM, Cherwek H, Taylor DA, Annex BH, (2002) Alterations in Endothelial Cell Proliferation and Apoptosis Contribute to Vascular Remodeling Following Hindlimb Ischemia in Rabbits; Vasc Med; May;7(2):87-91.

• Taylor DA, Hruban R, Rodriguez ER, Goldschmidt-Clermont PJ (2002) Cardiac Chimerism As A Mechanism for Self-Repair:  Does It Happen and If so to What Degree? Circulation Jul 2; 106(1):2-4.

• Taylor DA. (2002) Is In Vivo Remodeling Necessary or Sufficient for Cellular Repair of the Heart? Ann N.Y. Acad Sci,  Jun ;961:315-318.

• Dib N, Diethrich EB, Campbell A, Goodwin N, Robinson B, Gilbert J, Hobohm DW, Taylor DA.  (2002)  Endoventricular Transplantation of Allogenic Skeletal Myoblasts in a Porcine Model of Myocardial Infarction; J Endovasc Ther Jun; 9(3):313-319.

• van den Bos EJ, Taylor DA. (2003), Cardiac Transplantation of Skeletal Myoblasts for Heart Failure; Minerva Cardioangiologica, Apr; 51 (2): 227-243.

• Rauscher FM, Goldschmidt-Clermont PJ, Davis BH, Wang T, Gregg D, Ramaswami P, Pippen AM, Annex BH, Dong C, Taylor DA. (2003) Aging, Progenitor Cell Exhaustion, and Atherosclerosis; Circulation, Jul 29; 108 (4): 457-463.

• Thompson RB, Emani SM, Davis BH, van den Bos EJ, Morimoto Y, Craig D, Glower D, Taylor DA. (2003) Comparison of Intracardiac Cell Transplantation: Autologous Skeletal Myoblasts versus Bone Marrow Cells; Circulation Suppl Sep 9;108 1:II 264-71.

• Thompson RB, Parsa CJ, van den Bos EJ, Davis BH, Toloza EM, Klem I, Glower DD, Taylor DA, (2004) Video-assisted thoracoscopic transplantation of myoblasts into the heart; Ann Thorac Surg Jul;78(1):303-7.

• van den Bos EJ, Wagner A, Mahrholdt H, Thompson RB, Morimoto Y, Sutton BS, Judd RM, Taylor DA. (2003), Improved Efficacy of Stem Cell Labeling for Magnetic Resonance Imaging Studies by the use of Cationic Liposomes; Cell Transplantation 12(7): 743-56.

• van den Bos EJ, Davis BH, Taylor DA. (2004) Transplantation of skeletal myoblasts for cardiac repair; J Heart Lung Transplant. Nov;23(11):1217-27.

• van den Bos EJ, Thompson RB, Wagner A, Mahrholdt H, Morimoto Y, Thomson LE, Wang LH, Dunker DJ, Judd RM, Taylor DA. (2005) Functional assessment of myoblast transplantation for cardiac repair with magnetic resonance imaging; Eur J Heart Fail. Jun; 7(4):435-43.

• Thompson RB, van den Bos EJ, Davis BH, Morimoto Y, Craig D, Sutton BS, Glower DD, Taylor DA. (2005) Intracardiac Transplantation of a Mixed Population of Bone Marrow Cells Improves both Regional Systolic Contractility and Diastolic Relaxation; J Heart Lung Transplantation Feb;24(2):205-14.
  
  

• Zenovich AG, Taylor DA. (2007) Cell therapy in kidney disease: cautious optimism... but optimism nonetheless. Perit Dial Int. Jun;27 Suppl 2:S94-103.
  
  

• Nelson WD, Zenovich AG, Ott HC, Stolen C, Caron GJ, Panoskaltsis-Mortari A, Barnes SA 3rd, Xin X, Taylor DA. (2007) Sex-dependent attenuation of plaque growth after treatment with bone marrow mononuclear cells. Circ Res.Dec 7;101(12):1319-27.
  
  

• Zenovich AG, Davis BH, Taylor DA. (2007) Comparison of intracardiac cell transplantation: autologous skeletal myoblasts versus bone marrow cells. Handb Exp Pharmacol. (180):117-65.
  
  

• Davis BH, Schroeder T, Yarmolenko PS, Guilak F, Dewhirst MW, Taylor DA. (2007) An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy. Ann Biomed Eng. Aug;35(8):1414-24.
  
  

• Taylor DA, Zenovich AG. (2007) Cell therapy for left ventricular remodeling.Curr Heart Fail Rep. Mar;4(1):3-10.
  
  

• Maslov LN, Riabov VV, Sazonova SI, Taylor DA. (2006) [Regeneration of human myocardium] Patol Fiziol Eksp Ter. Oct-Dec;(4):28-32. Review. Russian.
  
  

• Ott HC, Matthiesen TS, Brechtken J, Grindle S, Goh SK, Nelson W, Taylor DA. (2007) The adult human heart as a source for stem cells: repair strategies with embryonic-like progenitor cells. Nat Clin Pract Cardiovasc Med. Feb;4 Suppl 1:S27-39.
  
  

• Ott HC, Taylor DA. (2006)  From cardiac repair to cardiac regeneration--ready to translate? Expert Opin Biol Ther. Sep;6(9):867-78.
  
  

• Ott HC, Brechtken J, Swingen C, Feldberg TM, Matthiesen TS, Barnes SA, Nelson W, Taylor DA. (2006) Robotic minimally invasive cell transplantation for heart failure.J Thorac Cardiovasc Surg. Jul;132(1):170-3.
  
  

• Emani SM, Ellis MJ, Dibernardo LR, Colgrove S, Glower DD, Taylor DA. (2006) Systolic contraction within aneurysmal rabbit myocardium following transplantation of autologous skeletal myoblasts.J Surg Res. Sep;135(1):202-8.