Sandeep Gupta

Sandeep Gupta is Assistant Professor of Medicine at the University of Minnesota.

Education

• M.B.B.S/M.D. from Government Medical College Nagpur, India.

• Residency in Internal Medicine and Fellowship in Nephrology from University of    Minnesota, Minneapolis, USA.

Research Interest

Working with Dr. Mark E. Rosenberg, their lab has isolated and characterized a multipotent renal progenitor cell (MRPC) from adult kidneys that has self-renewal and broad differentiation properties.

Current research focus of his laboratory is on:

1.  Determination of the stem cell niche in the adult kidneys.
2. Proteomics of the renal stem cells.
3. Stem cell lineage progression towards renal phenotype.
4. Therapeutic use of stem cells for kidney diseases.

Selected Publications

• Gupta, S, Verfaillie C, Chmielewski D, Kim Y, Rosenberg ME: A role for extrarenal cells in the regeneration following acute renal failure. Kidney Int 62:1285-90, 2002.
• Gupta, S, Verfaillie C, Chmielewski D, Kren S, Eidman K, Connaire J, Heremans Y, Lund T, Lenvik T, Blackstad M, Jiang Y, Luttun A, Rosenberg ME: Isolation, characterization of kidney derived stem cells. (Accepted for publication in JASN).

Publications in preparation

• Characterization of the renal stem cell niche in the adult kidney.
• Differentiation of renal stem cells towards renal phenotype.

Abstract

• Gupta S, Chmielewski D, Kren S, Verfaillie CM, Rosenberg ME. Role of kidney derived stem cells in the cellular therapy of acute renal failure. American Society of Nephrology, November 2004.
• Gupta S, Aronow BJ, Chmielewski D, Verfaillie C, RosenbergME: Gene expression profiling of adult kidney derived stem cells, American Society of Nephrology, November 2005.
• Gupta S, Aronow BJ, Chmielewski D, Verfaillie C, Rosenberg ME: Kidney derived stem cells: In vivo localization and cellular therapy. American Society of Nephrology, November 2005.
• Gupta S, Rosenberg ME: Oct-4 is an in vivo marker of adult renal stem cells. American Society of Nephrology, November 2006.
• Gupta S, Weber M, Rosenberg ME: Tubulogenesis in adult renal stem cells. American Society of Nephrology, November 2006.