Mark Rosenberg

rosen001@umn.edu

Mark Rosenberg is Professor of Medicine and Director of the Division of Renal Diseases and Hypertension at the University of Minnesota. 

His research is focused on the role of kidney stem cells in kidney regeneration following acute and chronic renal injury. Working with Dr. Sandeep Gupta, their lab has isolated and characterized a multipotent renal progenitor cell (MRPC) from adult kidneys that has self-renewal and broad differentiation properties. Studies are being performed in the following areas:

• Determining the differentiation potential of renal stem cells
• Defining the pathways of renal cell lineage progression
• Defining the renal stem cell niche
• The therapeutic use of renal and other stem cells in the therapy of acute renal failure
• Determining the role of renal stem cells in the pathophysiology of chronic renal diseases 

Selected Publications 

Gupta, S, Verfaillie C, Chmielewski D, Kim Y, Rosenberg ME: A role for extrarenal cells in the regeneration following acute renal failure. Kidney Int 62:1285-90,  2002

Gupta, S, Verfaillie C, Aronow BJ, Chmielewski D, Kren S, Solis S, Eidman K, Connaire J, Lakshmipati U, Heremans Y, Lund T, Lenvik T, Blackstad M, Jiang Y, Luttun A, Rosenberg ME: Isolation, characterization, and therapeutic delivery of kidney derived stem cells. (in revision)

Recent abstracts

Gupta S, Chmielewski D, Kren S, Verfaillie CM, Rosenberg ME. Role of kidney derived stem cells in the cellular therapy of acute renal failure. American Society of Nephrology, November 2004.

Gupta S, Aronow BJ, Chmielewski D, Verfaillie C, RosenbergME: Gene expression profiling of adult kidney derived stem cells, American Society of Nephrology, November 2005.

Gupta S, Aronow BJ, Chmielewski D, Verfaillie C, RosenbergME: Kidney derived stem cells: In vivo localization and cellular therapy. American Society of Nephrology, November 2005

Gupta S, Rosenberg ME: Oct-4 is an in vivo marker of adult renal stem cells. American Society of Nephrology, November 2006

Gupta S, Weber M, Rosenberg ME: Tubulogenesis in adult renal stem cells. American Society of Nephrology, November 2006