Our Faculty & Staff
Research Interests: Diabetes and metabolism roles of O-linked GlcNAc Transferase (OGT) signaling in pancreatic beta-cell development and programming of beta-cell susceptibility to diabetogenic conditions. Publications.
Research Interests: Development of magnetic resonance imaging (MRI)/spectroscopy (MRS) methodologies and the utilization of these methodologies for studying metabolism, bioenergetics and function of brain and other organs noninvasively. Publications.
Research Interests: Molecular mechanisms of aging and age-related macular degeneration, human primary retinal pigment epithelial cell cultures, using iPSC-RPE for drug testing, proteasome degradation of proteins, immunoproteasome, and proteomics.
Research Interests: Skeletal muscle stem cells; hematopoietic stem cells; modeling muscular dystrophies using iPS cells; facioscapulohumeral muscular dystrophy; hematopoietic-, cardiac-, and skeletal-myocyte differentiation of iPS cells. Publications.
Research Interests: Barriers to and drug therapies to increase hematopoietic stem cell homing after transplant in both zebrafish and mouse models; bone marrow transplant in storage diseases including ALD and Hurler syndrome. Publications.
Research Interests: Comparative approaches for studies of cancer biology, immunology, pathogenesis and therapeutic development. Interactions between tumor and mircoenvironment and fuctional/metabolic adaptations in the tumor niche. Functional analogies between stem cells and tumor propagating cells. Publications.
Research Interests: Cell inter-communication during tissue assembly of multicellular organisms using Drosophila as a model; elucidating the function of heparan sulfate proteoglycans (HSPGs) in development al processes such as growth factor signaling, cell adhesion, wound healing, and tumor metastasis. Publications.
Research Interests: Biomimetic 3-dimensional matrices for tissue engineering, transplantation, and in vitro applications; MSC applications to tissue engineering and roles in tumor stroma; pancreatic endocrine progenitor cells; islet transplantation. Publications.
Research Interests: Combining insights from mechanisms of stem cell differentiation/programming with engineering principles to replace damaged systems (e.g., cardiovascular). Spontaneous fusion of stem cells with mature cell types including cardiomyocytes, transcriptional profile of stem cell-cardiomyocyte fusion products, and how stem cells and their progeny interface with extracellular matrix proteins and the extent to which these interactions drive specification. Technologies under development include multiphoton flow cytometry, an enhanced-throughput analysis and sorting modality for the study of biologic particles of hundred to thousand micron scale. Publications.
Research Interests: Transcriptional mechanisms and signaling pathways controlling mesodermal cell fate; strategies to enable translational application of iPS cells to treat muscular dystrophies; genetic correction of disease- and patient-specific iPS cells; dissecting the mechanisms associated with hematopoietic stem cell self-renewal and long-term engraftment. Publications.
Research Interest: 1) The design of polymer-based delivery systems that encapsulate DNA and RNA for genetic disease treatments, 2) the development of polymer-based delivery systems for enhancing oral delivery of important peptides and drugs, and 3) the creation of sustainable and environmentally friendly polymers/plastics from naturally occurring chemicals derived from plants.
Research Interests: Developmental biology including regeneration of missing parts and transformation of one cell type into another. Author: Stem Cells: A Very Short Introduction (short guide for lay audience); Essential Developmental Biology (undergraduate textbook); upcoming in 2014, Genes: A Very Short Introduction. Publications.
Research Interests: Non-viral gene therapy for hepatic and non-hepatic diseases; microRNA studies in liver regeneration and colon cancer; blastocyst complementation with liver-derived progenitor cells to engineer pigs with human livers; and development of a unique anti-apoptotic bile acid for the treatment of a wide-ranging list of clinical disorders, including neurodegenerative diseases. Publications.
Distinguished McKnight Professor
Research Interests: Engineered arteries, valves, mycoardium, and microvessels; ERK-mediated fibroblast mechanotransduction and shear-mediated endothelial mechanotransduction; MSC-EC and iPS-CM. Publications.
Research Interests: Cardiac regeneration, tracking the activity of endogenous cardiac stem cells, biological pathways that regulate activation and differentiation of tissue-specific progenitor cells, finding new pathways that regulate cardiomyocyte proliferation. Publications.
Research Interests: Bone marrow transplant: hematopoietic recovery and engraftment after umbilical cord blood transplant; prevention of GvHD; development of novel conditioning regimens; development of novel cellular therapies. Publications.
Research interests: Our research is focused on the cell and molecular biology of leukocytes (white blood cells) to determine mechanisms that underlie damaging inflammation and to improve the immune response to cancer. A mechanism of interest is ectodomain shedding, a process by which membrane-associated proteases expressed by leukocytes regulate the surface density of various receptors important for leukocyte effector functions. An approach we are using to manipulate this process involves the genetic engineering of stem cells to derive leukocytes with improved abilities to locate and kill cancer cells. Publications.