Our Faculty & Staff

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Faculty

Atsushi Asakura, PhD
Associate Professor

612-624-7108
asakura@umn.edu

Research Interests: Muscle stem cell self-renewal and muscle regeneration using mouse genetics, and therapeutic approach for muscular dystrophy.

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Samira Azarin, PhD
Assistant Professor

612-301-3488
azarin@umn.edu

Research Interests: Engineering the cell microenvironment, regulation of cellular dormancy and activation, stem cell-based models of barrier function.

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Anindya Bagchi, PhD
Associate Professor

612-625-7598
bagch005@umn.edu

Research Interests: 8q24 gain in human cancer, role of p53 in cellular senescence, roles of endogenous retroviral elements and of CHD5 in cancer.

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Bruce Blazar, MD
Regents Professor

612-626-2734
blaza001@umn.edu

Research Interests: Immunobiology of transplantation: graft-versus-host disease, regulatory T cells, immune post-transplant, graft-versus-leukemia, gene therapy/repair.

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Wei Chen, PhD
Professor

612-625-8814
chenx075@umn.edu

Research Interests: Development of magnetic resonance imaging (MRI)/spectroscopy (MRS) methodologies and the utilization of these methodologies for studying metabolism, bioenergetics and function of brain and other organs noninvasively.

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Christina E. Clarkson, DVM, PhD
Assistant Professor

612-624-2267
clarkson@umn.edu

Research Interests: Development of Induced Pluripotent Stem cells and characterization of adult multipotent stem cell lines in large animal models which can be used for gene therapy.

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James R. Dutton, PhD
Research Assistant Professor

612-626-2762
dutto015@umn.edu

Research Interests: Cell reprogramming (liver to insulin expressing cells, skin fibroblasts to oligodendrocyte progenitors), clinical application of induced pluripotent cells.

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Karen Echeverri, PhD
Assistant Professor

612-626-7320
echev020@umn.edu

Research Interests: Regeneration, control of gene expression, and organ size control.

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Meri Firpo, PhD
Assistant Professor

612-625-3250
firpo001@umn.edu

Research Interests: Stem cell sources of cellular therapies, pancreatic development, regulation of self-renewal, transplantation therapies for diabetes, regeneration of islets.

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Daniel Garry, MD, PhD
Professor

612-626-0154
garry@umn.edu

Research Interests: Regenerative medicine, cardiogenesis, and stem-cell biology.

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Andrew Grande, MD
Assistant Professor

612-624-6666
grande@umn.edu

Research Interests: Identifying novel treatments for stroke using endogenous or exogenous stem cells.

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Timothy C. Hallstrom, PhD
Assistant Professor

612-626-2905
halls026@umn.edu

Research interests: Cellular control of Retinoblastoma(Rb)/E2F-induced apoptosis in cancer.

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Daniel Harki, PhD
Associate Professor

612-625-8687
daharki@umn.edu

Research Interests: Design, synthesis and biophysical characterization of small molecules that influence cellular function.

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Reuben Harris, PhD
Professor

612-624-0457
rsh@umn.edu

Research interests: DNA repair, epigenetics, Innate immunity, genetics, mutation research and therapeutics

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Wei-Shou Hu, PhD
Professor

612-625-0546
wshu@umn.edu

Research Interests: Hepatic differentiation from pluripotent stem cells, modeling of pluripotency regulation, stem cell metabolism and modeling, stem cell culture engineering.

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Allison Hubel, PhD
Professor

612-626-4451
hubel001@umn.edu

Research Interests: Preservation of stem cells and cells derived from stem cells for research and therapeutic applications.

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Steven S. Juhn, MD
Professor

612-626-9879
juhnx001@umn.edu

Research Interests: Otitis media, biochemistry of inner ear fluids, pathogenesis of Meniere's disease, mechanisms of age-related hearing loss and management, repair of inner ear organs by stem cell implantation.

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Yasuhiko Kawakami, PhD
Associate Professor

612-626-9935
kawak005@umn.edu

Research Interests: Limb development and appendicular skeletogenesis in mice, adult skeletal maintenance in mice, heart and fin regeneration in zebrafish.

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Susan A. Keirstead, PhD
Assistant Professor

612-626-2290
sakeir@umn.edu

Research Interests: Physiological characterization of stem cells and stem cell-derived cardiomyocytes, neurons, pancreatic beta cells, etc.

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Nobuaki J. Kikyo, MD, PhD
Associate Professor

612-624-0498
kikyo001@umn.edu

Research Interests: Chromatin remodeling in iPS cells, direct conversion of fibroblasts to cardiomyocytes, the role of long non-coding RNA in stem cells.

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Naoko Koyano-Nakagawa, PhD
Assistant Professor

612-625-7687
koyano@umn.edu

Research Interests: Transcriptional regulation of cardiovascular development and regeneration.

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Michael Kyba, PhD
Professor

612-626-5869
kyba@umn.edu

Research Interests: Skeletal muscle stem cells; hematopoietic stem cells; modeling muscular dystrophies using iPS cells; facioscapulohumeral muscular dystrophy; hematopoietic-, cardiac-, and skeletal-myocyte differentiation of iPS cells.

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Gufa Lin, MD, PhD
Research Assistant Professor

linxx519@umn.edu

Research Interests: Understanding and stimulating regeneration of the limb and the spinal cord, and progenitor cell differentiation from pluripotent stem cells.

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Walter Low, PhD
Professor

612-626-9203
lowwalt@umn.edu

Research Interests: Stem cells for the treatment of neurological disorders; adult pluripotent stem cells; human cord blood stem cells; generation of organs, tissues, and cells via blastocyst complementation.

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Troy Lund, MD, PhD
Associate Professor

612-625-4185
lundx072@umn.edu

Research Interests: Barriers to and drug therapies to increase hematopoietic stem cell homing after transplant in both zebrafish and mouse models; bone marrow transplant in storage diseases including ALD and Hurler syndrome.

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Jonathan S. Marchant, PhD
Professor

612-624-4664
march029@umn.edu

Research Interests: Planarian regeneration; calcium signaling and stem cell biology; pharmacological biasing of stem cell differentiation.

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Cindy M. Martin, MD
Assistant Professor

612-625-6173
cmmartin@umn.edu

Research Interests: Early cardiac progenitors, side-population cells, cardiovascular development and regeneration.

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Linda K. McLoon, PhD
Professor

612-626-0777
mcloo001@umn.edu

Research Interests: Skeletal muscle stem cells, with a focus on craniofacial muscles; muscle adaptation to injury and disease.

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Steven C. McLoon, PhD
Professor

612-624-9182
mcloons@umn.edu

Research Interests: Cellular mechanisms responsible for development of the vertebrate nervous system with an emphasis on the visual system.

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Joseph M. Metzger, PhD
Professor

612-625-8296
metzgerj@umn.edu

Research Interests: Integrative systems biology of cardiovascular function, cardiac gene therapy, transgenic models of heart disease, molecular mechanisms of sarcomere function, human iPS cell cardiac myocytes.

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Jaime Modiano, VMD, PhD
Professor

612-625-7436
modiano@umn.edu

Research Interests: Comparative approaches for studies of cancer biology, immunology, pathogenesis and therapeutic development. Interactions between tumor and mircoenvironment and fuctional/metabolic adaptations in the tumor niche. Functional analogies between stem cells and tumor propagating cells.

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Yasushi Nakagawa, MD, PhD
Associate Professor

612-625-4497
nakagawa@umn.edu

Research Interests: Control of progenitor cell fate in early brain development, developmental of the mammalian neocortex and thalamus, mechanisms of neurodevelopmental disorders, mouse genetics.

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Hiroshi Nakato, PhD
Associate Professor

612-625-1727
nakat003@umn.edu

Research Interests: Cell inter-communication during tissue assembly of multicellular organisms using Drosophila as a model; elucidating the function of heparan sulfate proteoglycans (HSPGs) in development al processes such as growth factor signaling, cell adhesion, wound healing, and tumor metastasis.

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Timothy D. O'Brien, DVM, PhD
Professor

612-625-8175
obrie004@umn.edu

Research Interests: Biomimetic 3-dimensional matrices for tissue engineering, transplantation, and in vitro applications; MSC applications to tissue engineering and roles in tumor stroma; pancreatic endocrine progenitor cells; islet transplantation.

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Brenda M. Ogle, PhD
Associate Professor

612-624-5948
ogle@umn.edu

Research Interests: Combining insights from mechanisms of stem cell differentiation/programming with engineering principles to replace damaged systems (e.g., cardiovascular). Spontaneous fusion of stem cells with mature cell types including cardiomyocytes, transcriptional profile of stem cell-cardiomyocyte fusion products, and how stem cells and their progeny interface with extracellular matrix proteins and the extent to which these interactions drive specification. Technologies under development include multiphoton flow cytometry, an enhanced-throughput analysis and sorting modality for the study of biologic particles of hundred to thousand micron scale.

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Mark J. Osborn, PhD
Assistant Professor

612-625-8327
osbor026@umn.edu

Research Interests: Molecular therapies for genetic disorders using gene editing technologies.

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Angela Panoskaltsis-Mortari, PhD
Professor

612-626-2950
panos001@umn.edu

Research Interests: Bioengineering lungs using stem cells; lung injury after post-hematopoietic stem cell transplant; cell-matrix interactions.

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Ann M. Parr, MD, PhD
Assistant Professor

612-625-4102
amparr@umn.edu

Research Interests: Direct conversion of fibroblasts to oligodendrocytes and neural stem cells, iPS cell technology, animal modeling of spinal cord injury, MRI imaging of spinal cord injury.

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Rita Perlingeiro, PhD
Professor

612-625-4984
perli032@umn.edu

Research Interests: Transcriptional mechanisms and signaling pathways controlling mesodermal cell fate; strategies to enable translational application of iPS cells to treat muscular dystrophies; genetic correction of disease- and patient-specific iPS cells; dissecting the mechanisms associated with hematopoietic stem cell self-renewal and long-term engraftment.

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Paolo Provenzano, PhD
Assistant Professor

612-624-3279
pprovenz@umn.edu

Research Interests: Quantitative cancer biology, cell-matrix interactions, signal transduction, mechanotransduction, advanced optical imaging/biophotonics.

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Casim A. Sarkar, PhD
Associate Professor

612-626-0525
csarkar@umn.edu

Research interests: Systems and synthetic biology approaches for understanding and engineering cellular decision making.

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Wei Shen, PhD
Associate Professor

612-624-3771
shenx104@umn.edu

Research Interests: Biomaterials engineering; cell-material interactions; using biomaterials to regulate stem cell fate, deliver cells, and regenerate tissues.

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Jonathan Slack, PhD
Professor Emeritus

612-624-9493
slack017@umn.edu

Research Interests: Developmental biology including regeneration of missing parts and transformation of one cell type into another. Author: Stem Cells: A Very Short Introduction (short guide for lay audience); Essential Developmental Biology (undergraduate textbook); upcoming in 2014, Genes: A Very Short Introduction.

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Clifford Steer, MD
Professor

612-624-6648
steer001@umn.edu

Research Interests: Non-viral gene therapy for hepatic and non-hepatic diseases; microRNA studies in liver regeneration and colon cancer; blastocyst complementation with liver-derived progenitor cells to engineer pigs with human livers; and development of a unique anti-apoptotic bile acid for the treatment of a wide-ranging list of clinical disorders, including neurodegenerative diseases

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Jakub Tolar, MD, PhD
Director, Distinguished McKnight Professor

612-626-6723
tolar003@umn.edu

Research Interests: Hematopoietic and epithelial stem cells, genome engineering, blood and marrow transplantation.

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Robert T. Tranquillo, PhD
Distinguished McKnight Professor

612-625-6868
tranquil@umn.edu

Research Interests: Engineered arteries, valves, mycoardium, and microvessels; ERK-mediated fibroblast mechanotransduction and shear-mediated endothelial mechanotransduction; MSC-EC and iPS-CM.

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John E. Wagner, MD
Professor

612-626-2961
wagne002@umn.edu

Research Interests: Bone marrow transplant: hematopoietic recovery and engraftment after umbilical cord blood transplant; prevention of GvHD; development of novel conditioning regimens; development of novel cellular therapies.

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Bruce Walcheck, PhD
Professor

612-624-2282
walch003@umn.edu

Research interests: Our research is focused on the cell and molecular biology of leukocytes (white blood cells) to determine mechanisms that underlie damaging inflammation and to improve the immune response to cancer. A mechanism of interest is ectodomain shedding, a process by which membrane-associated proteases expressed by leukocytes regulate the surface density of various receptors important for leukocyte effector functions. An approach we are using to manipulate this process involves the genetic engineering of stem cells to derive leukocytes with improved abilities to locate and kill cancer cells.

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Masato Yamamoto, MD, PhD
Professor

612-624-9131
yamam016@umn.edu

Research interests: Cancer gene therapy/virotherapy with emphasis on GI cancers. Application of gene-delivery technology to a variety of diseases and research.

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Jop van Berlo, MD, PhD
Assistant Professor

612-626-1853
jvanberl@umn.edu

Research Interests: Cardiac regeneration, tracking the activity of endogenous cardiac stem cells, biological pathways that regulate activation and differentiation of tissue-specific progenitor cells, finding new pathways that regulate cardiomyocyte proliferation.

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Staff

Lauri J. Andersen
Associate Administrator

612-625-0602
ander607@umn.edu

Learn more about Lauri at AHC Spotlight

Jesse Browers
Senior Laboratory Services Coordinator

612-624-3103
brow0760@umn.edu

Lydia McAnerney
Executive Office and Administrative Specialist

612- 625-1389
mcane001@umn.edu

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Nancy Morgan
Manager, Research Programs

612-626-6723
morga336@umn.edu

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