Andrew W. Grande, MD

Assistant Professor, Neurosurgery and Co-director, Earl Grande Stroke and Stem Cell Laboratory, Department of Neurosurgery

Andrew W. Grande

Contact Info

grande@umn.edu

Office Phone 612-624-6666

Office Address:
Department of Neurosurgery
MMC 96 Room D429
420 Delaware Street SE
Minneapolis, MN 55455

Mailing Address:
Neurosurgery Department
MMC 96 Mayo
8096A (Campus Delivery Code)
420 Delaware St SE
Minneapolis, MN 55455

Administrative Assistant Name
Deborah Fellows

Administrative Phone
612-624-6666

Administrative Email
fello62@umn.edu

Assistant Professor, Neurosurgery and Co-director, Earl Grande Stroke and Stem Cell Laboratory, Department of Neurosurgery


Neurosurgeon


Medical School, University of Minnesota

Residency, University of Cincinnati (Neurosurgery)

Fellowship, University of Cincinnati (Vascular/Endovascular Neurosurgery)

Fellowship, Ludwig-Maximilians University (Neural Stem Cells and Neurogenesis)

Summary

Dr. Andrew Grande originates from Minneapolis/St. Paul. He grew up in the Minneapolis lakes area and then later moved to St. Paul where he attended St. Thomas Academy for high school. He graduated from St. Olaf College (Northfield, MN) with a BA in chemistry and then attended the University of Minnesota Medical School. During college and medical school, he was very active in research activities at the University of Minnesota, working in the laboratories of Esam El. Fakahany, Virginia Seybold and Walter Low. These experiences later culminated in a burning curiosity and passion for the use of stem cells to treat stroke.

Dr. Grande completed his neurosurgical training at the Mayfield Clinic and University of Cincinnati. During his training, he worked very closely with Dr. John Tew, learning the nuances of trigeminal neuralgia treatment including both microvascular decompression and radiofrequency ablation. He then went on to complete a fellowship with Drs. Mario Zuccarello, Andrew Ringer and Todd Abruzzo at the University of Cincinnati in both endovascular and cerebrovascular neurosurgery. During this time, he had a significant exposure to intracranial bypass surgery for the treatment of Moya Moya disease and also cutting-edge endovascular treatments such as the use of Onyx glue for the treatment of cerebral aneurysms.

During his residency and then continuing into his fellowship, Dr. Grande was privileged to be involved in stem cell research with Professor Masato Nakafuku at Cincinnati Children’s Hospital. Professor Nakafuku was one of the first in the world to demonstrate neurogenesis in the hippocampus following stroke and he remains internationally recognized for his work with adult neurogenesis. In Professor Nakafuku’s laboratory, Dr. Grande’s research focused primarily on reprogramming cells within the cerebral cortex to form neurons following stroke. .

In 2010, Dr. Grande was the recipient of the William P. Van Wagenen Fellowship from the American Association of Neurological Surgeons. As a Van Wagenen Fellow, he traveled to Munich, Germany, where he completed a post-doctoral fellowship in the laboratory of Magdalena Gotz at Ludwig-Maximilians-Universitat. There he focused his research on identifying afferent connections to new neurons generated in the rodent cortex following a cortical layer specific injury.

Following his post-doctoral fellowship, Dr. Grande spent one month as a visiting Neurosurgeon with Professor Juha Hernesniemi in Helsinki, Finland.

Dr. Grande joined the University of Minnesota Department of Neurosurgery in 2011. His clinical interests are in the treatment of cerebral vascular diseases using either open vascular or endovascular techniques. He has specific interests in the treatment of complex aneurysms and Moya Moya disease. Additionally, Dr. Grande treats trigeminal neuralgia. Visit Dr. Grande's clinical web page.

Dr. Grande also directs the Earl Grande Stroke and Stem Cell Laboratory at the University of Minnesota. His research interest is focused on translating stem cell therapies for stroke from the bench to the bedside. Ongoing studies include exogenous cord blood stem cell transplantation for neuroprotection, reprogramming of reactive astrocytes to form neurons, and characterization of normal adult neural stem cells found in the brains of humans and other large animals.

Returning home to Minnesota, Dr. Grande is extremely committed and proud to treat Minnesota patients afflicted with neurological diseases.

“It has always been a dream of mine to be a neurosurgeon in Minnesota, in particular at the University of Minnesota. I was born and raised here, my entire family is here and there is nothing I enjoy more than interacting with Minnesota patients. When contemplating places to work, I only considered Minnesota; I just knew I could be a better neurosurgeon here. When facing neurosurgical diseases, I think there is something comforting in having a neurosurgeon with whom you have some connection.”

Philosophy of Care:

My philosophy is to care for others as I would my mother, father, wife or child. I ask my patients to call me “Andy” because it's important to be on a first name basis with those who entrust their lives with me. While neurosurgery is a world of unpredictable fates, I am committed to each patient to do my absolute best all the time.

Awards & Recognition

  • Champions of Care Award Recipient, Fairview Foundation, 2012
  • William P. Van Wagenen Award, American Association of Neurosurgeons, 2010
  • Ellen and Stewart B. Dunskar ,MD Award for Clinical Research, University of Cincinnati, 2009
    The University Hospital Health Alliance Doctor’s Day Award, University of Cincinnati, 2006

Professional Associations

  • Young Neurosurgeon’s Committee (American Association of Neurological Surgeons)
  • Congress of Neurological Surgeons
  • American Stroke Association
  • TNA/The Facial Pain Association
  • Minnesota Neurosurgical Society
  • Delegate to the Council of State Neurosurgical Societies
  • Frank H. Mayfield Society

Research

Research Summary/Interests

Research Interests

Dr. Grande also co-directs the Vel, Earl Grande, V. Richard Zarling Stroke, Stem Cell and Neuroimaging Laboratory at the University of Minnesota. His research interest is focused on the translation of stem cell therapies for stroke from the "bench to the bedside." Ongoing studies include exogenous cord blood stem cell transplantation for neuroprotection, reprogramming of reactive astrocytes to form neurons, and characterization of normal adult neural stem cells found in the brains of humans and other large animals.

Research Projects 

  • Regenerative Medicine Minnesota. (Ogle, PI; Grande Co-PI), “Design and Delivery of Advanced Therapeutics for the Treatment of Cerebrovascular Disease” ($93,780) 5/1/2015-4/30/2016
  • The National Science Foundation (Bin He, PI); (Andrew Grande, CO-I), “A Brain Centered Neuroengineering Approach for Motor Recovery after Stroke : Combined rTMS and BCI Training” ($321,360) September 1, 2013 – August 31, 2016

Publications

Basic Science

Neurosurgical

Chapters in Books

  • Stone LL, Low WC, Grande A. Stem Cell Therapies for Ischemic Stroke, in Laurent Lescaudron, Julien Rossignol, Gary L. Dunbar, eds. Stem Cells and Neurodegenerative Diseases, CRC Press (2013)
  • Nakafuku M, Grande A. (2013) Neurogenesis in the Damaged Mammalian Brain, Chapter 29. In John Rubenstein and Pasko Rakic, eds. Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience. Elsevier/Academic Press.
  • Morgan C, Grande A, Tew J. (2012) Percutaneous Stereotactic Rhizotomy in the Treatment of Intractable Facial Pain, Chapter 124. In Alfredo Quinones-Hinojosa ed. Schmidek & Sweet, Sixth Edition. Elsevier/Saunders
  • Ringer A, Nichols C, Khan S, Grande A, Khan U, Pyne-Geithman G, Abruzzo T. (2011) Angioplasty and Stenting for Management of Intracranial Arterial Stenosis. Hemorrhagic and Ischemic Stroke: Surgical, Interventional, Imaging, and Medical Approaches. Hemorrhagic and Ischemic Stroke: Medical, Imaging, Surgical and Interventional Approaches, Eds Bernard Bendok, Andrew Naidech, Matt Walker, and H. Hunt Batjer. Thieme
  • Nakafuku M, Grande A. (2011) Neurogenesis in the Damaged Mammalian Brain. Comprehensive Developmental Neuroscience, Chapter 74. Eds. Pasko Rakic and John Rubenstein. Elsevier Inc (Amsterdam)
  • Morgan C, Grande A, Tew J. (2011) Percutaneous Stereotactic Rhizotomy in the Treatment of Intractable Facial Pain. Schmidek & Sweet, Sixth Edition
  • Grande A, Nichols C, Khan U, Abruzzo T, Ringer A, Zuccarello M. (2011) Treatment of Post-Hemorrhagic Cerebral Vasospasm: role of endovascular therapy. Early Brain Injury or Cerebral Vasospasm, Acta Neurochirurgica Supplementum, Supplement Volume 110/2
  • Grande A., Morgan C., Tew J. (2011) Percutaneous Stereotactic Rhizotomy. Trigeminal Neuralgia Ed. Peter Jennetta. Oxford University Press (New York)
  • Tew J., Grande A., (2008) Percutaneous Stereotactic Radiofrequency Treatment of Trigeminal Neuralgia. COSMAN Procedure Technique Series
  • Choutka O., Grande A., Kuntz IV C. (2006) Posterior Thoracic Instrumentation with Pedicle Screws, Hooks, Wires, and Rods. Neurosurgical Operative Atlas, Spine and Peripheral Nerve
  • 2nd Edition

Other Published Articles

Clinical

Clinics

Neurosurgery Clinic

Board Certifications

American Board of Neurological Surgery

Clinical Interests

Cerebral aneurysms, arteriovenous malformations (AVMs); Carotid artery disease; Trigeminal neuralgia; Hemifacial spasm; Intracranial/extracranial stenosis; Moya Moya disease; Skull-base surgery; Stem cells and the treatment of stroke

Hospital Privileges

Fairview Ridges Hospital; Fairview Southdale Hospital; University of Minnesota Medical Center

Media

Video

Video

Why Andrew Grande Does What He Does

U of MN Health Sciences Expert Link

U of MN - Health Experts Page