Andrew W. Grande, MD

Assistant Professor and Co-director, Earl Grande, Vel, V. Richard Zerling Stroke, Stem Cell and Neuroimaging Laboratory, Department of Neurosurgery

Andrew W. Grande

Contact Info

grande@umn.edu

Office Phone 612-624-6666

Office Address:
Department of Neurosurgery
MMC 96 Room D429
420 Delaware Street SE
Minneapolis, MN 55455

Mailing Address:
Neurosurgery Department
MMC 96 Mayo
8096A (Campus Delivery Code)
420 Delaware St SE
Minneapolis, MN 55455

Administrative Assistant Name
Deborah Fellows

Administrative Phone
612-626-8786

Administrative Email
fello062@umn.edu

Assistant Professor and Co-director, Earl Grande, Vel, V. Richard Zerling Stroke, Stem Cell and Neuroimaging Laboratory, Department of Neurosurgery


Neurosurgeon


MD, University of Minnesota

Residency in Neurosurgery, University of Cincinnati

Fellowship in Vascular/Endocascular Neurosurgery, University of Cincinnati

Fellowship in Neural Stem Cells and Neurogenesis, Ludwig-Maximilians University, Germany

BA, St. Olaf College

Emerging Physicians Leadership Program, University of Minnesota

Minneapolis, MN, 2014-2017

Summary

Andrew Grande, MD, is from the Twin Cities. He grew up in the Minneapolis lakes area and then later moved to St. Paul where he attended high school at St. Thomas Academy. He graduated from St. Olaf College (Northfield, MN) with a BA in chemistry and then attended the University of Minnesota Medical School. During college and medical school, Dr. Grande was active in research, working in the laboratories of Drs Esam El Fakahany, Virginia Seybold and Walter Low. These experiences later culminated in a burning curiosity in and passion for using stem cells to treat stroke.

Dr. Grande completed his neurosurgical training at the Mayfield Clinic and University of Cincinnati. During his training, he worked very closely with Dr. John Tew, learning the nuances of trigeminal neuralgia treatment, including both microvascular decompression and radiofrequency ablation. He then went on to complete a fellowship with Mario Zuccarello, Andrew Ringer and Todd Abruzzo at the University of Cincinnati in both endovascular and cerebrovascular neurosurgery. During this time, Dr. Grande was exposed to intracranial bypass surgery for treating moyamoya disease and to cutting-edge endovascular treatments such as the use of Onyx glue for treating cerebral aneurysms.

During his residency and then continuing into his fellowship, Dr. Grande was involved in stem cell research with Dr. Masato Nakafuku at Cincinnati Children’s Hospital. Professor Nakafuku was one of the world's first to demonstrate neurogenesis in the hippocampus following stroke and he remains internationally recognized for his work with adult neurogenesis. In Nakafuku’s laboratory, Grande’s research focused primarily on reprogramming cells within the cerebral cortex to form neurons following stroke.

In 2010, Grande was the recipient of the William P. Van Wagenen Fellowship from the American Association of Neurological Surgeons. As a Van Wagenen Fellow, he traveled to Munich, Germany, where he completed a post-doctoral fellowship in the laboratory of Dr. Magdalena Gotz at Ludwig-Maximilians-Universitat. There he focused his research on identifying afferent connections to new neurons generated in the rodent cortex following a cortical layer specific injury.

Following his post-doctoral fellowship, Dr. Grande spent one month as a visiting neurosurgeon with Dr. Juha Hernesniemi in Helsinki, Finland.

Dr. Grande joined the University of Minnesota Department of Neurosurgery in 2011. His clinical interests are in treating cerebral vascular diseases, using either open vascular or endovascular techniques. He has specific interests in treating complex aneurysms, moyamoya disease, and trigeminal neuralgia.

Dr. Grande also directs the Earl Grande, Vel, V. Richard Zerling Stroke, Stem Cell and Neuroimaging Laboratory at the University of Minnesota. His research is focused on translating stem cell therapies for stroke from the bench to the bedside. Ongoing studies include exogenous cord blood stem cell transplantation for neuroprotection, reprogramming reactive astrocytes to form neurons, and characterizing normal adult neural stem cells found in the brains of humans and other large animals.

“It has always been a dream of mine to be a neurosurgeon in Minnesota, in particular at the University of Minnesota. I was born and raised here, my entire family is here and there is nothing I enjoy more than interacting with Minnesota patients. When contemplating places to work, I only considered Minnesota; I just knew I could be a better neurosurgeon here. I think there is something comforting in having a neurosurgeon with whom you have some connection.”

Philosophy of Care:

My philosophy is to care for others as I would my mother, father, wife or child. I ask my patients to call me “Andy” because it's important to be on a first name basis with those who entrust their lives with me. While neurosurgery is a world of unpredictable fates, I am committed to each patient to do my absolute best all the time.

Awards & Recognition

  • Mpls.St.Paul Magazine Top Doctors: Rising Stars 2017, 2018
    Champions of Care Award Recipient, Fairview Foundation, 2012, 2016
  • William P. Van Wagenen Award, American Association of Neurosurgeons, 2010
  • Ellen and Stewart B. Dunskar ,MD Award for Clinical Research, University of Cincinnati, 2009
    The University Hospital Health Alliance Doctor’s Day Award, University of Cincinnati, 2006
  • Society of Neurological Surgeons Research Award, RUNN Course 2006
  • AANS/CNS Cerebrovascular Section Resident Research Award 2006
  • The University Hospital Health Alliance Doctor’s Day Award 2006

Professional Associations

  • American Association of Neurological Surgeons
  • American Heart/American Stroke Association
  • Congress of Neurological Surgeons
  • Congress of State Neurosurgical Societies
  • Frank H. Mayfield Society
  • Minnesota Brain Injury Alliance
  • Minnesota State Neurological Society
  • Minnesota Stroke Association
  • Society of Neurointerventional Neurosurgery
  • The Facial Pain Association
  • William T. Peyton Society

Research

Research Summary/Interests

Research Interests
Dr. Grande co-directs the Earl Grande, Vel, V. Richard Zarling Stroke, Stem Cell and Neuroimaging Laboratory at the University of Minnesota. His research interest is focused translating stem cell therapies for stroke from the "bench to the bedside." Ongoing studies include exogenous cord blood stem cell transplantation for neuroprotection, reprogramming of reactive astrocytes to form neurons, and characterization of normal adult neural stem cells found in the brains of humans and other large animals.

Research Funding Grants

  • 2018 Minnesota Traumatic Brain Injury Research Grant Program (Grande, PI; Jagadeesan, Co-PI, Cheeran, Co-PI). “Therapeutic Application of Non-hematopoietic Umbilical Cord Blood Stem Cells (nh-UCBSCs) in Traumatic Brain Injury: Immune Modulation with Acute and Long Term Benefits”
  • National Institute of Diabetes and Digestive and Kidney Diseases (Steer, PI; Grande Co-I). “A Novel Stem Cell-based Approach for Generating Non-Human Primate Livers in Pigs”
  • NIH-NINDS (Local = Mustapha Ezzeddine, PI; Grande, Co-I. National = Joe Broderick, PI), “NINDS Stroke Trials Network - Regional Coordinating Center.”

Publications

Impact Analytics

h-Index h(fl)-Index Total Publications First/Last Author Publications Total Citations First/Last Author Citations
9 9 30 12 339

Publications

Peer-Reviewed Publications (most recent)

  1. Blackburn Spiros; Swisher Christa B; Grande Andrew W; Rubi Alba; Verbick Laura Zitella; McCabe Aaron; Lad Shivanand P. Filtration of SAH via Spinal Catheter. Operative Neurosurgery. In Press.
  2. Barnes J Todd; Cozzens Jeffrey; Grande Andrew; Toms Steven A; Webb Sharon Zusman Edie; Origitano TC; Pennicooke Brenton; Jost Fouke Sarah. Impact of Hospital and Health System Mergers and Acquisitions on the Practicing Neurosurgeon; Survey and Analysis from the CSNS Medical Director's Ad-Hoc Representative Section. Neurosurgery. In Press.
  3. Yagmur Kaan; Kalani Yashar; Bozkurt Baran; Belykh Evgenii; Grande Andrew; Preul Mark; Spetzler Robert. Anterior temporal artery to posterior cerebral artery bypass for revascularization of the posterior circulation: An anatomical study. Journal of Clinical Neuroscience. 2018, Jan 47:337-340. PMID 29110993.
  4. Johnson Nessa; Carey James; Edelman Bradley; Doud Alexander; Grande Andrew; Lakshminarayan Kamakshi; He Bin. Combined rTMS and Virtual Reality Brain-Computer Interface Training for Motor Recovery after Stroke. Journal of Neural Engineering. 2017, In Press. PMID 28914232
  5. Chaddad-Neto F, Devanir Silva da Costa M, Bozkurt B, Leonardo Doria-Netto H, de Araujo Paz D, da Silva Centeno R, Grande AW, Cavalheiro S, Ya?murlu K, Spetzler RF, Preul MC. Contralateral anterior interhemispheric, transcallosal, transrostral approach to the subcallosal region. A novel surgical technique. Journal of Neurosurgery. 2017, In Press. PMID 29099298. Impact Factor 3.73
  6. Lim JJ, Ladd BM, Grande AW, Haines SJ. Prepackaged Instrument Kit for Percutaneous Balloon Compression Rhizotomy for the Treatment of Trigeminal Neuralgia: Improvised Solution for an Unexpected National Supply Shortage. Operative Neurosurgery. 2017, In Press. Impact Factor 3.78
  7. Bozkurt B, Yagmurlu K, Middlebrooks E, Cayci Z, Cevik O, Karadag A, Moen S, Yanriover N, Grande AW. Fiber Connections of the Supplementary Morot Area Revisited: Methodology of Fiber Dissection, DTI, and Three-Dimensional Documentation. Journal of Visualization Experiments. 2017, In Press. Impact Factor 1.1
  8. Grande AW et al. Contralateral anterior interhemispheric, transcallosal, transrostral approach to the subcallosal region. A novel surgical technique. Journal of Neurosurgery. 2017, In Press. Impact Factor 3.73
  9. Senoglu M, Karadag A, Kinali B, Bozkurt B, Middlebrooks E, Grande AW. Cortical Bone Trajectory Screw for Lumbar Fixation: A Quantitative Anatomical and Morphometric Evaluation. Laboratory Investigation. World Neurosurgery. 2017. In press, available online on 3 May 2017. PMID 28478246. Impact Factor 2.878
  10. Cramer SC, Wolf SL, Adams HP Jr, Chen D, Dromerick AW, Dunning K, Ellerbe C, Grande A, Janis S, Lansberg MG, Lazar RM, Palesch YY, Richards L, Roth E, Savitz S, Wechsler LR, Wintermark M, Broderick JP. Stroke Recovery and Rehabilitation Research: Issues, Opportunities, and the National Institutes of Health StrokeNet. Stroke. 2017, Mar;48(3):813-819. PMID: 28174324. Impact Factor 5.787. Cited: 1.
  11. Bozkurt B, da Silva Centeno R, Chaddad-Neto F, Goiri MA, Karadaq A, Tugcu B, Ovalioglu TC, Tannover N, Kaya S, Yagmurlu K, Grande A. Transcortical Selective Amygdalohippocampectomy Technique through the Middle Temporal Gyrus Revisited. An Anatomical Study Laboratory Investigation. J Clinical Neuroscience, 2016. Dec;34:237-245. PMID: 27499121.
  12. Jagadeesan BD, Sandhu D, Hong KJ, Roshan Khanipour S, Grande AW, Tummala RP. Salvage of herniated flow diverters using stent and balloon anchoring techniques: A technical note. Interventional Neurology, 2016, November, 6:31-35. DOI:10.1159/000452284.
  13. Bozkurt B, Yagmurlu K, Middlebrooks EH, Karadag A, Ovalioglu, TC, Jagadeesan B, Sandhu G, Tanriover N, Grande AW. The Microsurgical and Tractographic Anatomy of the Supplementary Motor Area Complex in Human.World Neurosurgery, 2016. November, 95: 99-107. PMID: 27476690. Impact Factor: 2.685.
  14. Ladd B, Tackla RD, Gupte A, Darrow D, Sorenson J, Zuccarello M, Grande AW. Feasibility of telementoring for micro neurosurgical procedures utilizing a microscope, a proof-of-concept study. World Neurosurgery. 2017 Mar; 99:680-686. Impact Factor: 2.69
  15. Lim JJ, Clark HB, Grande AW. Isolated Hypertrophic Neuropathy of the Oculomotor Nerve. World Neurosurg. 2017 Feb;98:880e1-880. PMID: 27876664. Impact Factor: 2.69

Non-Peer-Reviewed Publications

  1. Grande A, Grewal S. (2014) Allergic to Nickel? Be Sure to Let Your Doctor Know! The Mayfield Brain & Spinal Column Roles: Guarantor of integrity of entire study; developed study concept; developed study design; conducted literature research; conducted experimental studies; data acquisition; manuscript editing; manuscript review
  2. Grande A. (2013)Making the Leap from Bench to Bedside: The Promise and Present State of Stem Cell Therapy in Treating Stroke. Minnesota Physician 26(11) Roles: Guarantor of integrity of entire study; developed study concept; developed study design; defined intellectual content; conducted literature research; manuscript preparation; manuscript editing; manuscript review
  3. Grande A, Tummala R, Jagadeesan B (2012) Carotid Artery Disease-Heading to the OR to Reduce the Risk of Stroke. Minnesota Physician 26(5) Roles: Guarantor of integrity of entire study; developed study concept; developed study design; defined intellectual content; conducted literature research; manuscript preparation; manuscript editing; manuscript review

Chapters in Books

  1. Robertson J, Sorenson J, Grande A, Brown M. Visualization and Optics in Neurosurgery. In Youmans and Winn Neurological Surgery, 7/e, 2016.
  2. Ringer AJ, Grande AW, Grossman AW, Andaluz N, Abruzzo T and Zuccarello M. Diagnosis and Treatment of Post-Hemorrhagic Cerebral Vasospasm. In Youmans and Winn Neurological Surgery, 7/e, 2016.
  3. Stone LL, Low WC, Grande A. Stem Cell Therapies for Ischemic Stroke, In Laurent Lescaudron, Julien Rossignol, Gary L. Dunbar, eds. Stem Cells and Neurodegenerative Diseases, CRC Press (2013) Roles: Guarantor of integrity of entire study; manuscript editing; manuscript review
  4. Nakafuku M, Grande A. (2013) Neurogenesis in the Damaged Mammalian Brain, Chapter 29. In John Rubenstein and Pasko Rakic, eds. Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience. Elsevier/Academic Press. Roles: Conducted literature research; manuscript preparation; manuscript editing; manuscript review
  5. Morgan C, Grande A, Tew J. (2012) Percutaneous Stereotactic Rhizotomy in the Treatment of Intractable Facial Pain, Chapter 124. In Alfredo Quinones-Hinojosa ed. Schmidek & Sweet, Sixth Edition. Elsevier/Saunders Roles: Conducted literature research; manuscript preparation; manuscript editing; manuscript review
  6. Ringer A, Nichols C, Khan S, Grande A, Khan U, Pyne-Geithman G, Abruzzo T. (2011) Angioplasty and Stenting for Management of Intracranial Arterial Stenosis, Chapter 31. In Bernard Bendok, Andrew Naidech, and Hunt Batjer, eds. Hemorrhagic and Ischemic Stroke: Surgical, Interventional, Imaging, and Medical Approaches. Thieme Roles: Guarantor of integrity of entire study; manuscript preparation; manuscript editing; manuscript review
  7. Grande A., Morgan C., Tew J. (2011) Percutaneous Stereotactic Rhizotomy. In Peter Jennetta, eds, Trigeminal Neuralgia, Oxford University Press (New York) Roles: Guarantor of integrity of entire study; conducted literature research; manuscript preparation; manuscript editing
  8. Tew J., Grande A., (2008) Percutaneous Stereotactic Radiofrequency Treatment of Trigeminal Neuralgia. COSMAN Procedure Technique Series Roles: Guarantor of integrity of entire study; defined intellectual content; conducted literature research; manuscript preparation; manuscript editing
  9. Choutka O., Grande A., Kuntz IV C. (2006) Posterior Thoracic Instrumentation with Pedicle Screws, Hooks, Wires, and Rods. Neurosurgical Operative Atlas, Spine and Peripheral Nerve 2nd Edition Roles: Manuscript editing; manuscript review

Presentations

Invited Oral Presentations at International Professional Meetings, Conferences, etc.

  1. Clinical Trials: Bench to Clinic. Saudi Association of Neurological Surgery Annual Meeting & 2nd Arab Pediatric Neurosurgery Annual Meeting Joint Conference. Riyadh, Saudi Arabia. 8 April 2017.
  2. Stem Cells Therapy in the Central Nervous System: Bench to Clinic. Saudi Association of Neurological Surgery Annual Meeting & 2nd Arab Pediatric Neurosurgery Annual Meeting Joint Conference. Riyadh, Saudi Arabia. 8 April 2017
  3. Training in Endovascular Neurosurgery: Dual Trained Neurosurgeons Panel Discussion, Neurovascon Conference, Bangalore, India, September 2014
  4. Treatment of Aneurysms - Moving Forward with a Toolbox Approach, Keynote Speaker, Neurosurgery Alor Star Summit, Penang, Malaysia, April 2012
  5. Trigeminal Neuralgia: Different Treatment, Neurosurgery Alor Star Summit, Penang, Malaysia, April 2012
  6. Evolving Treatments for Stroke - A New Renaissance, Keynote Speaker, Neurosurgery Alor Star Summit, Penang, Malaysia, April 2012
  7. Single Center Experience with Onyx HD500 for Intracranial Aneurysms: Is general anesthesia required?, Invited Speaker, Technical University, Department of Neurosurgery, München, Germany, 2011
  8. Microscopic and Endoscopic Approaches to the Skull Base Course, Laboratory Instructor, Laproscopic Training Center, Strasbourg, France 2011

Invited Oral Presentations at National Professional Meetings, Conferences, etc. (Most Recent)

  1. Stem Cells Therapy for Stroke. 2018 AANS Annual Scientific Meeting. New Orleans LA. 2 May 2018.
  2. Advancing Surgical Robotics in Neurosurgery. 2018 Design of Medical Devices Conference. University of Minnesota, Minneapolis, MN. April 10, 2018.
  3. Stroke is a Neurological Disease. AANS/NREF Endovascular and Vascular Techiques Course, MERI Lab, Memphis TN. October 20-21, 2017.
  4. AVM Surgery: Lessons Learned. AANS/NREF Endovascular and Vascular Techiques Course, MERI Lab, Memphis TN. October 20-21, 2017.
  5. Trigeminal Neuralgia. Ozarks Neurosurgery Education Clinic, Speaker and Instructor, ONE Clinic, Trigeminal Neuralgia. Ridgedale, MO, August 25, 2017
  6. AVM Complication: Hemorrhage during preoperative embolization of grade II AVM. Cerebrovascular Complications Conference, Jackson Hole, WY. June 26, 2017Stroke Complication Involving Worse Neurological Examination after Attempted Thrombectomy. Cerebrovascular Complications Conference, Jackson Hole, WY. June 27, 2017.
  7. Complications of Angiography – Avoidance & Management. Endovascular 101: Introduction to Cerebral Angiography & Endovascular Surgical Neuroradiology. Teton Village, WY. June 28, 2017.
  8. Device Compatibility: How to Read a Label. Endovascular 101: Introduction to Cerebral Angiography & Endovascular Surgical Neuroradiology. Teton Village, WY. June 28, 2017.
  9. Leadership in Neurosurgery: Critical for our future success. 2017 Mayfield Alumnus Lecturer. University of Cincinnati, Mayfield Clinic, Cincinnati, OH. June 2, 2017.
  10. Pathophysiology of Trigeminal Neuralgia and Mechanism Directed Therapy. The Winter Clinics for Cranial and Spinal Surgery. Snowmass, CO. March 1, 2017.
  11. Reprogramming for the Treatment of Stroke. Invited speaker. American Academy of Neurological Surgery, Jackson Hole, CO, September 15, 2016
  12. Trigeminal Neuralgia: Surgical Treatment. Facial Pain Association Regional Conference. Minneapolis, MN. September 10, 2016
  13. Ozarks Neurosurgery Education Clinic, Speaker and Instructor, ONE Clinic, Neurosurgery Approach and Overview, Ridgedale, MO, August 2016.
  14. Applications of Video and 3D Technology in Neurosurgery, Invited speaker and Instructor, AANS 2016 Annual Meeting, Chicago IL, May 2016.
  15. Trigeminal Neuralgia. 9th Annual Avera Brain and Spine Institute Conference. Avera, SD. March 2016.
  16. Foramen Oval Observations to the Practical Aspects of Performing a PSR. Invited Speaker. 2016 Winter Clinics for Cranial & Spinal Surgery. Snowmass, CO. February 2016.

Clinical

Clinics

Clinics and Surgery Center;Neurosurgery Clinic

Board Certifications

American Board of Neurosurgeons, Diplomate

Clinical Interests

Cerebral aneurysms, arteriovenous malformations (AVMs); Carotid artery disease; Trigeminal neuralgia; Hemifacial spasm; Intracranial/extracranial stenosis; Moya Moya disease; Skull-base surgery; Stem cells and the treatment of stroke

Hospital Privileges

Fairview Health Systems Fairview University Medical Center Fairview Southdale Hospital Hennepin County Medical Center Park Nicollet Methodist Hospital Minneapolis VA Medical Center

Community Engagement

Minnesota Brain Injury Alliance 2011-present

  • Board Member, elected 2013-present
  • Advocacy Committee, appointed 2012-present

Minnesota Stroke Association 2011-present

  • Partnership Committee, appointed 2011-present
  • Conference Planning Committee, appointed 2011-present

Media

Video

Video

Why Andrew Grande Does What He Does

U of MN Health Sciences Expert Link

U of MN - Health Experts Page