Angela Panoskaltsis-Mortari, PhD

Professor of Medicine (Joint Appointment), Division of Pulmonary, Allergy, Critical Care and Sleep Medicine

Angela Panoskaltsis-Mortari

Contact Info

panos001@umn.edu

Office Address:
Pediatric BMT
660E MCRB
425 E River Pkwy
Minneapolis, MN 55455

Mailing Address:
Pediatrics BMT
420 Delaware St SE
MMC 366 Mayo
8366A (Campus Delivery Code)
Minneapolis, MN 55455

Administrative Assistant Name
PACCS

Administrative Phone
612-624-0999

Administrative Email
paccmed@umn.edu

Administrative Fax Number
612-625-2174

Professor of Medicine (Joint Appointment), Division of Pulmonary, Allergy, Critical Care and Sleep Medicine

Department of Pediatrics

Director, Cytokine Reference Laboratory


Pathology Fellowship, University of Alabama, Tuscaloosa, AL

Pediatric BMT, Fellowship, University of Minnesota, Minneapolis MN

PhD, University of Western Ontario, London, ON, Canada

MSc, The University of Western Ontario, London, ON, Canada

Summary

Angela Panoskaltsis-Mortari, Ph.D. is a Professor of Pediatrics in the Division of Blood and Marrow Transplantation and the Division of Pulmonary Medicine. Dr. Panoskaltsis-Mortari is the Director of the Cytokine Reference Laboratory.

Dr. Panoskaltsis-Mortari received her PhD from the University of Western Ontario. She was a post-doctoral fellow in the Department of Pathology at the University of Alabama and a post-doctoral research associate in the Department of Pediatrics at the University of Minnesota. She joined the University of Minnesota faculty in 1995.

Panoskaltsis-Mortari has board certification from the American Board of Medical Laboratory Immunology. She is a member of numerous immunology, pulmonary and hematology professional societies, and the author of nearly 120 articles which have appeared in such publications as Journal of Experimental Medicine, Journal of Clinical Investigation, Blood, Biology of Blood and Marrow Transplantation, American Journal of Physiology (Lung, Cell. & Mol. Physiol.) and Journal of Immunology.

Research

Research Summary/Interests

Dr. Panoskaltsis-Mortari’s laboratory research focuses upon bioengineering the lung using adult stem cells and decellularized whole lung scaffolds with the goal of creating autologous lungs for transplant. The Mortari lab also studies bone-marrow transplant-related lung injuries such as idiopathic pneumonia syndrome and obliterative bronchiolitis which are major complications causing morbidity and mortality post-BMT. She is also exploring methods of enhancing proper lung repair in several lung injury models using mesenchymal stromal cells, anti-fibrotic interventions and novel antioxidants.

Publications

A selection of Dr. Panoskaltsis-Mortari ‘s recent publications.

  • Wendt C, Tram K, Price AP, England K, Stiehm A, Panoskaltsis-Mortari A. Clara Cell Secretory Protein improves Survival in a Murine Obliterative Bronchiolitis Model. Amer. J. Physiol: Lung Cell. Mol. Physiol., 305:642-650, 2013.
  • Hall MW, Guo C-Y, Panoskaltsis-Mortari A, Jouvet P, Ferdinands J, Shay D, Nateri J, Greathouse K, Sullivan R, Kiesling S, Randolph AG for the PALISI Network PICFlu Study Investigators. Innate Immune Function and Mortality in Critically Ill Children and Young Adults with Influenza: A Multi-Center Study. Crit. Care Med., 41, 224-236, 2013.
  • Yi D, Wiedmann TS, Naqwi A, Price A, Panoskaltsis-Mortari A. Distribution of aerosols in lungs of mice with obliterative bronchiolitis by fluorescent imaging. Exp. Lung Res. 38:325-332, 2012.
  • Srinivasan M, Flynn R, Price A, Ranger A, Browning JL, Taylor PA, Ritz J, Antin JH, Murphy WJ, Luznik L, Shlomchik MJ, Panoskaltsis-Mortari A*, Blazar BR* (co-senior authors). Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood. 119(6):1570-80, 2012.
  • England KA, Price AP, Tram KV, Shapiro SD, Blazar BR, Panoskaltsis-Mortari A. Evidence for early fibrosis and increased airway resistance in bone marrow transplant recipient mice deficient in MMP12. Amer J Physiol: Lung, Cell. Mol. Physiol. 301:L519-526, 2011.
  • Price AP, England K, Matson A, Blazar BR, Panoskaltsis-Mortari A. Development of a decellularized lung bioreactor system for bioengineering the lung: The matrix reloaded. Tissue Engineering, 16:2581-2591, 2010.

Click here to see a complete list of Dr. Panoskaltsis-Mortari’s studies which have been published by academic and research journals. 

Clinical

Board Certifications

American Board of Medical Laboratory Immunology