Ann M. Parr, MD, PhD

Assistant Professor, Department of Neurosurgery

Ann M. Parr

Contact Info

amparr@umn.edu

Mailing Address:
Department of Neurosurgery
MMC 96
420 Delaware St. SE
Minneapolis, MN 55455

Administrative Assistant Name
Claire Graham

Administrative Phone
612-624-6666

Administrative Email
clgraham@umn.edu

Assistant Professor, Department of Neurosurgery

Director, Spinal Neurosurgery


Neurosurgeon


Medical School, Queens University

Residency, University of Toronto (Neurosurgery)

Fellowship, University of Miami (Complex Spine)

Summary

Dr. Parr is interested in finding new therapies for spinal cord injury. She is also a faculty member in the Graduate Program in Neuroscience and the Stem Cell Institute.

Awards & Recognition

  • Research Education, Training, and Career Development (CTSI-Ed) Travel Award, 2014
  • Paul Harris Fellow, The Rotary Foundation of Rotary International, 2013
  • AAMC Early Career Women Faculty Professional Development Conference, 2011
  • AANS/CNS Cahill Spine Fellowship, 2009 – 2010
  • SPINEFEST Poster Competition first prize, 2008
  • AANS/CNS Section on Disorders of the Spine and Peripheral Nerves – Mayfield Basic Science Award, 2008
  • Regional Award Winner – ACS Trauma Competition, 2007
  • Canadian Institutes of Health Research Fellowship (CIHR), 2006
  • McMurrich Poster Competition second prize – University of Toronto Gallie Day, 2006
  • TWRI Research Day Poster Competition second prize, 2006
  • Top Abstracts – National Neurotrauma Society, 2005
  • Ontario Neurotrauma Foundation Spinal Cord Injury Scholarship, 2005
  • AANS/CNS Codman Fellowship in Neurotrauma and Critical Care, 2004
  • PARIM Clinical Resident Award, 2002
  • Thomas Gibson Scholarship for highest overall standing in Pharmacology, 1998
  • Bristol-Myers Squibb Award for acceptance of an abstract for oral presentation, 1998
  • John F. Sparks Summer Student Research Scholarship – Division of Plastic Surgery, 1997
  • Aesculapian Society Summer Project Award – Nairobi, Kenya, 1996
  • PMAC-HRF/MRC Summer Student Research Scholarship – Dept. of Pharmacology, 1995
  • PMAC-HRF/MRC Summer Student Research Scholarship – Dept. of Pharmacology, 1994
  • Canada Scholar (4 year recipient), 1991 – 1995
  • Queen's University Anniversary Scholarship, 1991

Research

Research Summary/Interests

Dr. Parr's research currently centers around transplanting neural stem cells grown from a patient's own skin into the injured spinal cord. She has an active translational research laboratory at the Stem Cell Institute. She is interested in examining mechanisms of functional recovery using techniques such as histology and immunohistochemistry, cell tracking through magnetic resonance imaging, and animal modeling.

Research Funding Grants

  • Wings for Life,“Autologous Oligodendrocyte Progenitor Cell Therapy in Chronic Spinal Cord Injury,” PI, $110,000, 7/1/14 – 6/30/15
  • CTSI KL2 Scholar (NIH CON000000033119-3002), “Autologous Oligodendrocyte Progenitor Cells for Transplantation in Spinal Cord Injury,” PI, 3/1/2014 – 2/28/2017
  • Institute of Engineering in Medicine, University of Minnesota, “Organ, Tissue, and Cell Engineering,” Co-I (PI-Walt Low), $20,000, 2014-2015
  • Institute of Engineering in Medicine, University of Minnesota, “Nanotechnology Development and Applications for Clinical Neuroscience,” Co-I (PI-Walt Low), $75,000, 2014-2015
  • University of Minnesota Foundation, “Autologous Oligodendrocyte Progenitor Cells for Transplantation in Spinal Cord Injury,” PI, 11/1/11 -

Publications

Book Chapters

  • Walsh P, K Voltzke, Parr AM, and Dutton JR (2015) cGMP Production of Human iPS Cells,AABB Cellular Therapy: Principles, Methods, and Regulations, 2nd edition, in press.
  • Walsh P, Truong V, Parr, AM and Dutton JR (2015) cGMP-compliant expansion of human iPSC cultures as adherent monolayers, Methods in Molecular Biology, Ed. Kurstad T., Springer NY, in press.

Lectures Online

"New Therapies for Spinal Cord Injuries", March 7, 2011

Publications

  • Satzer D, DiBartolomeo C, Ritchie MM, Storino C, Liimatainen T, Hakkarainen H, Idiyatullin D, Mangia S, Michaeli S*, Parr AM*, LowWC*. Assessment of dysmyelination with RAFFn MRI: Application to murine MPS I. PlosOne in press, 2014. *co-senior authors. PMID: 25680196
  • Parr AM, Wang MY. CT alone may be inadequate for detecting occult spinal injuries. Neurosurgery’s Science Times 66(4) N23-4, 2010. PMID: 20305484
  • Wang MY, Parr AM. An international initiative to define the role for surgery for spinal metastases: The GSTSG. World Neurosurgery 73(5) 426-7, 2010. PMID: 20920912
  • Parr AM, Wang MY. Preoperative erythropoietin prior to spinal surgery increases DVT risk. Neurosurgery's Science Times 66(2) N16, 2010.
  • Parr AM, Wang MY. Vertebroplasty: effective or not? Neurosurgery's Science Times 65(6) N14, 2009.
  • Parr AM, Wang MY. Minimally invasive lumbar discectomy had worse outcome than conventional open microdiscectomy. Neurosurgery's Science Times 65(1) N12, 2009.
  • Mothe AJ, Kulbatski I, Parr AM, Mohareb M, and Tator CH. Adult spinal cord stem/progenitor cells transplanted as neurospheres preferentially differentiate into oligodendrocytes in the adult rat spinal cord. Cell Transplant 17(7) 735-51, 2008.
  • Kulbatski I, Mothe AJ, Parr AM, Kim H, Kang CE, Bozkurt G, and Tator CH. Glial precursor cell transplantation therapy for neurotrauma and multiple sclerosis. Prog Histochem Cytochem 43(3) 123-76, 2008.
  • Parr AM, Kulbatski I, Zahir T, Wang X, Yue C, Keating A, and Tator CH. Transplanted adult spinal cord-derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury. Neuroscience 155(3) 760-70, 2008.
  • Parr AM, Kulbatski I, Wang XH, Keating A, and Tator CH. Fate of transplanted adult neural stem/progenitor cells and bone marrow-derived mesenchymal stromal cells in the injured adult rat spinal cord and impact on functional recovery. Surg Neurol 70(6) 600-7, 2008.
  • Parr AM, and Tator CH. Intrathecal epidermal growth factor and fibroblast growth factor-2 exacerbate meningeal proliferative lesions associated with intrathecal catheters. Neurosurgery 60(5) 926-33, 2007.
  • Parr AM, Kulbatski I, and Tator CH. Transplantation of adult rat spinal cord stem/progenitor cells for spinal cord injury. J Neurotrauma 24(5) 835-45, 2007.

Posters and Abstracts

  • Dutton JR, Subramaniam S, Maxon J, Voltzke K, Baden J, Walsh P and Parr AM. Manufacturing hiPS cell derived Oligodendrocyte Progenitor Cells for Autologous Therapy. 2014 World Stem Cells Regenerative Medicine Congress, London, England, 2014.
  • Parr AM, Subramaniam S, Lee C, Dutton J. Differentiation of human induced pluripotent stem cells into oligodendrocyte progenitor cells. AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, Orlando, FL, 2014.
  • Parr AM, Terzic D, Subramaniam S, and Dutton J. Development of Autologous Oligodendrocyte Progenitor Cells for Transplantation in Spinal Cord Injury. XV WFNS World Congress of Neurosurgery, Seoul, Korea, 2013.
  • Subramaniam S, Lee C, Dutton J, Parr AM. Differentiation of human induced pluripotent stem cells into oligodendrocyte progenitor cells. 22nd Annual University of Minnesota Developmental Biology Symposium, Minneapolis, MN, 2013.
  • Subramaniam S, Lee C, Dutton J, Parr AM. Differentiation of human induced pluripotent stem cells into oligodendrocyte progenitor cells. 8th Annual LifeScience Alley (LSA) Conference, Minneapolis, MN, 2013.
  • Terzic T, Parr AM, Ritchie MM, Goyal T, Dibartolomeo CS and Dutton JR. An Improved Method for Generating Oligodendrocyte Progenitor Cells from Murine Induced Pluripotent Stem Cells. MN Neurosurgical Society Meeting, Red Wing, MN, 2013.
  • Subramaniam S, Lee C, Dutton J, Parr AM. Differentiation of human induced pluripotent stem cells into oligodendrocyte progenitor cells. The New York Stem Cell Foundation’s 8th Annual Translational Stem Cell Research Conference, New York, 2013
  • Parr AM. Autologous oligodendrocyte progenitor cells for transplantation in spinal cord injury. AOSpine Fellows Meeting, Banff, 2012.
  • Terzic D, Dutton JR, Parr AM. Generation of Oligodendrocyte Progenitor Cells from Mouse Fibroblasts using an Induced Pluripotent Cell Intermediary. CNS Annual Meeting, Chicago, IL, 2012.
  • Parr AM, Levene HB, and Levi AD. Superparamagnetic iron oxide nanoparticles for identification of Schwann cells in vivo after transplantation in a porcine model of spinal cord injury. AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves, Orlando, FL, 2010.
  • Parr AM, Kulbatski I, Zahir T, Wang X, Yue C, Keating A, and Tator CH. Transplanted adult spinal cord-derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury. AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves, Orlando, FL, 2008.
  • Parr AM, Kulbatski I, Wang X, Keating A, Tator CH. Survival and fate of adult rat bone marrow stromal cells versus spinal cord stem/progenitor cells in the injured adult rat spinal cord. 1st Canadian Spinal Cord Injury Conference, Banff, Alberta, 2006.
  • Parr AM, Kulbatski I, Wang X, Keating A, Tator CH. Survival and fate of adult rat bone marrow stromal cells versus spinal cord stem/progenitor cells in the injured adult rat spinal cord. American Association of Neurological Surgeons, San Francisco, CA, 2006.
  • Parr AM, Kulbatski I, Wang X, Keating A, Tator CH. Survival, fate, and implications for functional recovery of adult rat spinal cord stem/progenitor cells and bone marrow stromal cells in the injured adult rat spinal cord. Congress of Neurological Surgeons, Chicago, IL, 2006.
  • Parr AM, Kulbatski I, Tator CH. Transplantation of adult rat spinal cord ependymal region stem/progenitor cells into the injured adult rat spinal cord. American Association of Neurological Surgeons, New Orleans, LA, 2005.
  • Parr AM, Kulbatski I, Tator CH. Transplantation of adult rat spinal cord ependymal region stem/progenitor cells into the injured adult rat spinal cord. 40th Annual Canadian Congress of Neurological Sciences, Ottowa, Canada, 2005.
  • Parr AM, Kulbatski I, Tator CH. Transplantation of adult rat spinal cord ependymal region stem/progenitor cells into the injured adult rat spinal cord. World Federation of Neurological Surgeons, Marrakesh, Morocco, 2005.
  • Parr AM, Kulbatski I, Tator CH. Transplantation of adult rat spinal cord ependymal region stem/progenitor cells into the injured adult rat spinal cord. National Neurotrauma Society, Washington DC, 2005.
  • Parr AM, Wang X, Keating A, Tator CH. Transplantation of adult rat bone marrow stromal cells into the injured adult rat spinal cord. National Neurotrauma Society, Washington DC,2005.
  • Parr AM, Tator CH. The role of neurotrophic factors on endogenous ependymal region cells in the repair of acute spinal cord injury in the adult rat. 39th Annual Canadian Congress of Neurological Sciences, Calgary, Canada, 2004.
  • Parr AM, Kulbatski I, Tator CH. Transplantation of adult rat spinal cord ependymal region stem/progenitor cells into the injured adult rat spinal cord. Neurotrauma Society, San Diego, CA, 2004.
  • Parr AM, Kulbatski I, Tator CH. Transplantation of adult rat spinal cord ependymal region stem/progenitor cells into the injured adult rat spinal cord. Congress of Neurological Surgeons, San Francisco, CA, 2004.
  • Tsai EC, Poon PCK, Parr AM, Tator CH. Anatomical basis for a novel mechanism underlying functional locomotor recovery after spinal cord repair. Program in Neurosciences Research Day, University of Toronto (2003).
  • Parr AM, West M. Intracranial hemorrhage and infectious intracranial aneurysm in bacterial endocarditis. 38th Annual Canadian Congress of Neurological Sciences, Quebec City, Canada, 2003.
  • Parr AM, West M. Intracranial hemorrhage and infectious intracranial aneurysm in bacterial endocarditis. Annual Meeting of the Winnipeg branch of the American College of Surgeons, Winnipeg, Canada, 2002.
  • Parr AM, Zoutman DE, Davidson JS. Antimicrobial activity of lidocaine. 52nd Annual Meeting of the Canadian Society of Plastic Surgeons, Victoria, B.C. (published in Can J Plast Surg, 6(1):56-57; 1998.
  • Brien JF, Parr AM, Cook MN, Kimura KA, Reynolds JD. Nitric oxide synthase and heme oxygenase activity in the hippocampus of the guinea pig:ontogeny and ethanol exposure. Alcoholism. Clin Exp Res, 19(2):48A, 1995.
  • Kimura KA, Parr AM, Brien JF. Nitric oxide synthase in the hippocampus of the developing guinea pig:ontogeny and effect of chronic prenatal ethanol exposure. 19th Annual Ontario-Quebec Perinatal Investigators’ Meeting, 1995.
  • Kimura KA, Parr AM, Brien JF. Chronic prenatal ethanol exposure decreases nitric oxide synthase activity and restricts growth in the hippocampus in the near-term fetal guinea pig. Society of Toxicology of Canada Annual Symposium, 1995.

Clinical

Clinics

Neurosurgery Clinic

Board Certifications

FRCSC (Fellow of the Royal College of Surgeons of Canada)

Clinical Interests

Spine; General neurosurgery; Complex spinal surgery; Minimally invasive spinal surgery