Jonathan S. Marchant, PhD

Professor, Department of Pharmacology

Jonathan S. Marchant

Contact Info

march029@umn.edu

Office Phone 612-624-4664

Office Address:
NHH 2-106

Mailing Address:
Pharmacology
Room 6-120 JacH
1213A (Campus Delivery Code)
321 Church St SE
Minneapolis, MN 55455

PhD, University of Cambridge

Summary

Our laboratory investigates the cell biology of Ca2+ signaling processes and the role and dysfunction of Ca2+ channels in neuro-regenerative and neuro-degenerative biology. Current projects encompass drug development efforts for agents that bias stem cell differentiation toward neurogenic fates, with the goal of uncovering tools to promote CNS regeneration. In an invertebrate model, we have resolved a molecular pharmacophore that promotes brain formation, generating compounds that prove surprisingly impactful as antiparasitic agents which are undergoing preclinical evaluation. We are also working to understand the workings of recently discovered endolysosomal Ca2+channels called two-pore channels (TPCs), and their role in organellar dysfunctions seen in degenerative states, infectious disease and lysosomal storage disorders. Check out our projects on our lab web site.

Dr. Marchant is Director of the Stem Cell biology T32 training program.

Research

Research Summary/Interests

The business of Ca2+ signaling is one of information delivery, and it’s hard to think of any cell process that is not regulated by Ca2+. Ca2+ signals also direct cell fate, and we are interested in the role of Ca2+ in directing stem cell differentiation and neurogenesis. Our current work examines regeneration of planarian flatworms as a simple paradigm for understand how Ca2+ signals bias regeneration toward CNS formation. We are examining whether ‘pharmacological engineering’ – using drugs to engage particular Ca2+ fluxes in vivo – can be used to promote neurogenesis. This is pure, simple, enjoyable basic science: with potential impact for studying human diseases from neurodegenerative conditions to a surprising relevance to infectious diseases that infect millions of people worldwide.Our breadth in pursuing problems with diverse approaches – from single molecule-level investigations into cell signaling architecture up to tissue regeneration studies in vivo – represents our mojo that trainees must have broad scope in bringing the best suited methods to bear on key research questions that motivate them.Check out our projects on our lab web site.

Publications