Jop van Berlo, MD, PhD

Lois and Richard King Assistant Professor of Medicine, Cardiovascular Division

Jop van Berlo

Contact Info

jvanberl@umn.edu

Fax 612-301-8298

Lab Phone 612-301-5248

Office Address:
Cancer & Cardiovascular Research Building
4-140
2231 6th Street SE
Minneapolis, Minnesota 55455

Mailing Address:
Cancer & Cardiovascular Research Building
Lillehei Heart Institute
1st floor Mailroom CCRB
2231 6th Street SE
Minneapolis, Minnesota 55455

Lab Address:
Cancer & Cardiovascular Research Building
4-220
2231 6th Street SE
Minneapolis, Minnesota 55455

Administrative Assistant Name
Jane Hutchins-Peterson

Administrative Phone
612-626-2505

Administrative Email
jhutchin@umn.edu

Administrative Fax Number
612-301-8298

Lois and Richard King Assistant Professor of Medicine, Cardiovascular Division

Assistant Professor, Lillehei Endowed Scholar, Lillehei Heart Institute


Medical School, University of Maastricht, Maastricht, Netherlands (2001)

Cardiology Residency, University Hospital Maastricht, Maastricht, Netherlands (2006)

Post-doctoral Research at the Howard Hughes Medical Institute, Division of Molecular Cardiovascular Biology, Cincinnati, OH

PhD, University Maastricht and University Hospital, Maastricht, Netherlands

Summary

After obtaining his M.D. and Ph.D. degrees from the University of Maastricht, the Netherlands, Dr. Jop van Berlo performed postdoctoral research with Dr. Jeffery Molkentin at the Howard Hughes Medical Institute, Cincinnati Children’s Hospital Medical Center. There he initiated a research program focused on cardiac regeneration, which he further developed upon joining the University of Minnesota Faculty in 2013.

Awards & Recognition

  • 2013 Finalist Melvin L. Marcus Young Investigator Award 
  • 2012 NIH Pathway to Independence Award (K99/R00) from National Heart Lung and Blood Institute
  • 2011 Winner, International Society for Heart Research (ISHR) International Poster Competition
  • 2010 Postdoctoral Fellowship, American Heart Association, Great Rivers Affiliate
  • 2009 Winner, University of Cincinnati Research Council Postdoctoral Research Fellowship
  • 2007 Rubicon Fellowship from Netherlands Organisation for Scientific Research (NWO)
  • 2006 Postdoctoral Fellowship from Interuniversity Cardiology Institute Netherlands (ICIN)
  • 2004 Winner, Poster prize 40th anniversary Scientific Sessions Netherlands Heart Foundation
  • 2002 Dekker Award, Ph.D. training award for MDs from Netherlands Heart Foundation

Professional Associations

  • MSTP Research Preceptor
  • MSTP Steering Committee
  • IBP Graduate Faculty
  • IBP Graduate Program Steering Committee
  • Stem Cell Institute Graduate Faculty
  • Stem Cell Institute Leadership Team                                                       

Research

Research Summary/Interests

My laboratory studies mechanisms of cardiac regeneration. The goal of this research is to develop innovative strategies to enhance the limited ability of the heart to regenerate. To identify these strategies, we study the underlying mechanisms of endogenous regeneration. We are interested in the signaling pathways that determine lineage specification of adult cardiac progenitor cells. Understanding of how these progenitor cells decide to become cardiomyocytes or endothelial cells may lead to development of therapeutics that stimulate preferential differentiation towards cardiomyocytes. We are further studying the impediments for cardiac regeneration, and are finding ways to boost the proliferative ability of cardiomyocytes.

Publications

A complete list of publication can be found at:
http://www.ncbi.nlm.nih.gov/sites/myncbi/johannes.van berlo.1/bibliography/45984132/public/?sort=date&direction=ascending
or at:
https://experts.umn.edu/en/persons/jop-van-berlo

  • Yellamilli A and van Berlo JH. The Role of Cardiac Side Population Cells in Cardiac Regeneration. Front Cell Dev Biol. 2016 Sep 13.
  • Van Berlo JH and Molkentin JD. An Emerging Consensus on Cardiac Regeneration. Nat Med. 2014 Dec;20(12):1386-93
  • Van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC, Middleton RC, Marbán E, Molkentin JD. C-kit+ Cells Minimally Contribute Cardiomyocytes in the Heart. Nature. 2014 May 15;509(7500):337-41
  • Van Berlo JH, Maillet M, Molkentin JD. Signaling Effectors Underlying Pathologic Growth and Remodeling of the Heart. J Clin Invest. 2013 Jan;123(1):37-45
  • Van Berlo JH, Elrod JW, Aronow BJ, Pu WT, Molkentin JD. Serine 105 Phosphorylation of Transcription Factor GATA4 Is Necessary for Stress-Induced Cardiac Hypertrophy in Vivo. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12331-6