Rita Perlingeiro, PhD

Professor of Medicine, Cardiovascular Division

Rita Perlingeiro

Contact Info

perli032@umn.edu

Fax 612-301-8298

Office Address:
Cardiovascular Division
Cancer & Cardiovascular Research Building
Lillehei Heart Institute
4th Floor
2231 6th Street SE
Minneapolis, Minnesota 55455

Mailing Address:
Cancer & Cardiovascular Research Building
Lillehei Heart Institute
1st floor Mailroom CCRB
2231 6th Street SE
Minneapolis, Minnesota 55455

Administrative Email
perli032@umn.edu

Professor of Medicine, Cardiovascular Division


Postdoctoral Fellowship, Whitehead Institute for Biomedical Research, MIT, Cambridge, MA

BSc, Biochemistry and Pharmacy Federal University of Santa Maria, Santa Maria-R.S., Brazil

Summary

Our laboratory has a long-term interest in understanding the molecular mechanisms controlling lineage-specific differentiation of pluripotent stem cells (i.e. embryonic and adult reprogrammed stem cells), and applying this information to efficiently generate tissue-specific stem/progenitor cells endowed with in vivo regenerative potential. Our ultimate goal is to develop safe strategies to enable their future therapeutic application.

Awards & Recognition

  • Lillehei Professorship in Stem Cell and Regenerative Cardiovascular Medicine (2014)
  • National Scientist Development Award from AHA (2005)
  • Postdoctoral Fellowship from FAPESP, Government of Sao Paulo, Brazil (1999)
  • FAPESP Summer Research Award (1996)
  • PhD Fellowship from FAPESP, Government of Sao Paulo, Brazil
  • PhD Fellowship from CAPES, Government of Brazil (declined) (1993)
  • Master’s Fellowship from FAPESP, Government of Sao Paulo, Brazil (1991)

Professional Associations

Committees:

  • Member of the Musculo-Skeletal Gene & Cell Therapy Committee – ASGCT (2014-2017)
  • Skills and Development Coordinator for NHLBI Progenitor Cell Biology Consortium (2013 - Present)

Editorial Board:

  • Skeletal Muscle, Journal of Stem Cell Research and Therapy, and Stem Cell Reviews and Reports

Research

Research Summary/Interests

Research Projects

  • Transcriptional mechanisms and signaling pathways controlling mesodermal cell fate
  • Strategies to enable translational application of iPS cells to treat muscular dystrophies
  • Genetic correction of disease- and patient-specific iPS cells
  • Dissecting the mechanisms associated with hematopoietic stem cell self-renewal in homeostasis and leukemia

Research Funding Grants

  1. Skeletal Muscle Regeneration from Differentiating Pluripotent Stem Cells, R01 AR055299, National Institutes of Health – NIAMS, Principal Investigator, $220,000, 07/01/07 - 08/31/19 (direct cost, annual project period)
  2. Midwestern Progenitor Cell Consortium, U01 HL100407, National Institutes of Health – NHLBI, Principal Investigator Project 3 (Multiple PIs), $109,283, 07/01/12 - 12/31/16 NCE (direct cost, annual project period)

Publications

  • BaikJ, MagliA, TaharaN, SwansonSA, BorgesL, Koyano-NakagawaN, StewartR, GarryDG, Kawakami Y, ThomsonJA & Perlingeiro RCR. Endoglin Integrates BMP and Wnt Signaling to Induce Hematopoiesis through JDP2. Nature Communications. in press
  • Carrió E, Magli A, Muñoz M, Peinado MA, Perlingeiro RCR, & Suelves M. Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation. BMC Biology. 2016:14:30. PMCID: PMC in progress
  • Filareto A, Rinaldi F, Arpke RW, Darabi R, Belanto JJ, Toso EA, Miller AZ, Ervasti JM, McIvor RS, Kyba M, & Perlingeiro RCR. Pax3-induced expansion enables the genetic correction of dystrophic satellite cells. Skeletal Muscle. 2015:5:36. PMCID: PMC4620645
  • McCullagh KJA & Perlingeiro RCR. Coaxing stem cells for skeletal muscle repair. Advanced Drug Delivery Reviews. 2015:84:198-207. PMID: 25049085
  • Skoglund G, Laine J, Darabi R, Fournier E, Perlingeiro RCR, Tabti N, (2014) “Physiological and ultrastructural features of human induced pluripotent and embryonic stem cell-derived skeletal myocytes in vitro.” Proc Natl Acad Sci USA. 111:8275-8280. 
  • Magli A, Schnettler E, Swanson SA, Borges L, Hoffman K, Stewart R, Thomson JA, Perlingeiro RCR, (2014) “Pax3 and Tbx5 specify whether PDGFR?+ cells assume skeletal or cardiac muscle fate in differentiating ES cells”. Stem Cells, 32:2072-2083. PMID: 24677751.
  • Filareto A, Parker S, Darabi R, Borges L, Iacovino M, Schaaf T, Mayerhofer T, Chamberlain JS, Ervasti JM, McIvor RS, Kyba M, Perlingeiro RCR, (2013) “An Ex Vivo Gene Therapy Approach to Treat Muscular Dystrophy Using Inducible Pluripotent Stem Cells” Nat Communication, Mar 5;4:1549. PMID: 23462992. 
  • Magli A, Schnettler E, Rinaldi F, Brember P, Perlingeiro RCR, (2013) “Functional Dissection of Pax3 in Paraxial Mesoderm Development and Myogenesis” Stem Cells, Jan; 31(1):59-60. PMID: 23081715.
  • Borges L, Iacovino M, Mayerhofer T, Koyano-Nakagawa N, Baik J, Garry DJ, Kyba M, Letarte M, Perlingeiro RCR, (2012) “A Critical Role for Endoglin in the Emergence of Blood During Embryonic Development” Blood, Jun 7;119(23):5417-5428. PMID: 22535663. 
  • Darabi R, Arpke RW, Irion S, Dimos JT, Grskovic M, Kyba M, Perlingeiro RCR, (2012) "Human ES- and iPS-Derived Myogenic Progenitors Restore DYSTROPHIN and Improve Contractility upon Transplantation in Dystrophic Mice"Cell Stem Cell, May 4;10(5):610-9. PMID:22560081. 
  • Darabi R, Santos FNC, Filareto A, Pan W, Koene R, Rudnicki M, Kyba M, Perlingeiro RCR, (2011) "Assessment of the Myogenic Stem Cell Compartment Following Transplantation of Pax3/Pax7-Induced Embryonic Stem Cell-Derived Progenitors" Stem Cells, 29:777-790. 
  • Darabi R, Gehlbach K, Stull JT, Kamm KE, Kyba M, Perlingeiro RCR, (2008) "Functional skeletal muscle regeneration from differentiating embryonic stem cells" Nature Medicine, 14:134-143