Walter C. Low, PhD

Professor, Department of Neurosurgery

Walter C. Low

Contact Info

lowwalt@umn.edu

Office Phone 612-626-9203

Office Address:
Neurosurgery Department
LRB/MTRF
2001 6th St SE, Rm 4-216
Minneapolis, MN 55455

Mailing Address:
Neurosurgery
LRB/MTRF
2873J (Campus Delivery Code)
2001 6th St SE
Minneapolis, MN 55455

Fellowship, University of Cambridge

PhD, University of Michigan (Bioengineering)

MS, University of Michigan

BS in Electrical Engineering and Computer Science, University of California

Summary

Dr. Walter Low is a Professor in the Department of Neurosurgery and serves as the Associate Head for Research. He earned his PhD in Bioengineering from the University of Michigan, and was a National Science Foundation/NATO Fellow in Neurophysiology/Neuroscience at the University of Cambridge in England. He is currently Director of the Research Laboratories in the Department of Neurosurgery.

Dr. Low was formerly on the faculty at Indiana University School of Medicine where he was the Director of the Graduate Program in Physiology and Biophysics. He has served as a member of numerous grant review study sections for the National Institutes of Health, the National Science Foundation, and the Veterans Administration Medical Centers.

The h-index for the scientific impact of Dr. Low’s research publications is ranked above the 95th percentile among faculty in neurosurgery departments in the United States. 

Awards & Recognition

  • Who’s Who in America, 2002, 2005, 2007
  • Who’s Who in Medical Science Education, 2005
  • Thorne Stroke Award – Minnesota Medical Foundation, 2003
  • Who’s Who in Stem Cell Research, 2003
  • American Men and Women of Science, 2002
  • Who’s Who Among America’s Teachers, 2002

Research

Research Summary/Interests

Dr. Low’s research is focused on translating neuroscience developments from the laboratory to the clinic. He has been involved in a number of technologies that include neural progenitor/stem cell therapies, gene therapies, neuroprotective therapies, and medical devices for treating a variety of neurological conditions. Neural disorders of interest include ischemic and hemorrhagic stroke, Parkinson’s disease, brain tumors, Alzheimer’s disease, lysosomal storage disorders of the brain, Huntington’s disease, spinal cord injury, and traumatic brain injury.

Dr. Low’s group was the first to:

  • Demonstrate that the transplantation of cholinergic neurons into the hippocampal formation could restore learning and memory function in a rat model of Alzheimer’s disease
  • Demonstrate the efficacy of immunotherapy for eradicating intracranial tumors in rodents
  • Receive FDA approval for clinical trials in the United States to study the efficacy of deep brain stimulation for the treatment of Parkinson’s disease.

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Research Funding Grants

  • 2017-2019 – Regenerative Medicine Minnesota, “Production of Dopamine Neurons – A Cellular Product for Treating Parkinson’s Disease," (Principal Investigator)
  • 2017-2019 – NIH MN-REACH Program, “Midbrain Organoid-Derived Product for Treatment of Parkinson’s Disease." (Co-Investigator)
  • 2017-2018 – Randy Shaver Cancer Research Foundation, “Harnessing the Zika Virus to Target Malignant Brain Tumors," (Principal Investigator)
  • 2016-2018 – Regenerative Medicine Minnesota, “Generating Human Neural Stem Cells and Progenitor Cells in a Porcine Model Through Blastocyst Complementation," (Co-Investigator)
  • 2016-2018 – Academic Health Center, University of Minnesota, “Generating Human Pancreas in Gene Edited Pigs," (Co-Principal Investigator)
  • 2016-2018 – Minnesota Partnership Infrastructure Fund, State of Minnesota, “3-Dimensional Nanoscale Resolution Microscope for Understanding Human Disease Processes," (Co-Investigator)
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Patents

  • “Magnetic Brain Array for Neuron Modulation and Mapping”, University of Minnesota Docket # 20150177 (2015)
  • “Engineering of Humanized Dopamine Neurons by Genetic Complementation," University of Minnesota and Recombinetics (2015)
  • “Adeno-Associated Virus Mediated Gene Transfer to the Central Nervous System, University of Minnesota Docket No. 600.915PRV, Serial No. 61/823,757 (2013)
  • “Vaccine Therapeutic Composition and Methods for Treating or Inhibiting Glioblastoma” U.S. Patent Application Serial No.: 61/406,429 (2010), PCT/US2011/057654 (2011), U.S. Patent No. 9,364,505 B2 (June 14, 2016)
  • “Ovarian Cancer Prognosis”, U.S. Patent Application Serial No.: 61/481,556 (2011) 

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Publications

Dr. Low's publications have received more than 15,967 citations in the scientific literature. Seventeen articles have received more than 100 citations. The h-index for the scientific impact of these publications is 54 and is ranked above the 95th percentile among faculty in academic neurosurgery departments in the United States. Following are a selection:

  • Laoharawee K, Podetz-Pedersen K, Nguyen T, Fairbanks C, Low WC, Kozarsky K, and McIvor RS, Prevention of neurocognitive deficiency in mucopolysaccharidosis type II mice by CNS-directed AAV9-mediated sulfatase gene transfer, Human Gene Therapy, ePub ahead of print (2017)
  • Belur LR, Temme A, Podetz-Pedersen KM, Riedl M, Vulchanova L, Robinson N, Hanson LR, Kozarsky K, Frey WH, Low WC, and McIvor RS, Intranasal AAV mediated gene delivery and expression of human iduronidase in the CNS: A non-invasive and effective approach for prevention of neurologic disease in mucopolysaccharidosis type I. Human Gene Therapy, ePub ahead of print (2017)
  • Gardeck AM, Sheehan J, and Low WC, Immune and viral therapies for brain cancer. Expert Opinion on Biological Therapies 17:457-474 (2017)
  • Lehto LJ, Slopsema JP, Johnson MD, Shatillo A, Teplitzky B, Utecht L, Adriany G, Mangia S, Sierra A, Low WC, Grohn O, and Machaeli S, Orientation selective deep brain stimulation, Journal of Neural Engineering, 14:016016 ePub ahead of print (2017)
  • Parry GJ, Rodrigues CMP, Low WC, Hilbert SJ, and Steer CJ, Ursodeoxycholic acid may slow progression of amyotrophic later sclerosis. Annals of Neurodegenerative Disorders ePub ahead of print (2016).
  • Stone LLH, Xiao F, Rotshafer J, Juliano M, Sanberg CD, Sanberg PR, Kuzmin-Nichol N, Grande A, Cheeran MC, and Low WC. Amelioration of ischemic brain injury in rats with human umbilical cord blood stem cells: Mechanisms of action, Cell Transplantation, 25:1473-1488 (2016).
  • Terzic D, Maxon JR, Krevitt L, DiBartolomeo, Goyal T, Dutton JR, Low WC, and Parr AM, Directed differentiation of oligodendrocyte progenitor cells from mouse induced pluripotent stem cells, Cell Transplantation, 25:411-424 (2016).
  • Satzer, D, Miller, C, Maxon J, Dibartolomeo C, Dutton JR, Low WC, and Parr AM, T cell deficiency in spinal cord injury – altered locomotor recovery and whole-genome transcriptional analysis, BMC Neuroscience16:74 Epub ahead of print (2015).
  • Divani AA, Murphy AJ, Meints J, Sadeghi-Bzargani H, Nordberg J, Monga M, Low WC, Bhatia PM, Beilman GJ, and SantaCruz KS, A novel preclinical model of moderate primary blast-induced traumatic brain injury, Journal of Neurotrauma, 32:1109-1116 (2015).
  • Satzer D, DiBartolomeao C, Ritchie MM, Storino C, Idiyatullin D, Mangia S, Michaeli S, Parr AM, and Low WC, Assessment of dysmyelination with RAFF MRI – application to murine MPS I, PLoS ONE 10:e0116788 (2015).

Books

  • Low WC and CM Verfaillie, Editors, Stem Cells and Regenerative Medicine, World Science Press, Hakensack, NJ, (2008)
  • Low, W.C., Analysis of Neurophysiological Plasticity within the Hippocampal Formation, University Microfilms, Xerox Corporation, Ann Arbor, Michigan (1979).

Chapters in Books (Selected)

  • Stone LL, Low WC, and Grande A. Stem cell therapies for ischemic stroke, in Stem Cells in Neurogenerative Disease, Ed. by L Lescaudron, J Rossignol, and GL Dunbar, CRC Press, London, UK, pgs. 142-156, (2014).
  • Keene CD, Ortiz-Gonzalez XR, Jiang Y, Verfaillie CM, and Low WC, Therapeutic application of bone marrow- derived stem cells in neuralgic injury and disease. In: Cell Therapies for Central Nervous System Disorders, Ed. by P.R. Sanberg, Humana Press (2005).
  • Triarhou, L.C., W.C. Low, and B. Ghetti, Neurological mutant mice as models in neural transplantation, In: Intracerebral Transplantation, Ed. by Q.Y. Xu and S. S Jiao, The Science Press, Beijing, pp. 66-72 (2000).
  • Low, W.C. and Y.J. Li, Neural transplantation of dopamine containing tissue into the striatum of animals with nigrostriatal dopamine deficits, In: Intracerebral Transplantation, Ed. by Q.Y. Xu and S. S Jiao, The Science Press, Beijing, pp. 78-85 (2000).
  • Low, W.C. and Y.J. Li, Intrahippocampal grafts of cholinergic neurons: Survival, innervation, and functional restoration, In: Intracerebral Transplantation, Ed. by Q.Y. Xu and S. S Jiao, The Science Press, Beijing, pp. 108-113 (2000).

Posters (Selected)

  • Toman N, Shaio ML, Voth J, Danczyk G, and Low WC, Assessing the ability of the Zika virus to infect human GBM6 and U87 gliomas, Peyton Society 80th Anniversary Meeting, Minneapolis, MN 2017
  • Pearce CM, Shiao ML, and Low WC, Zika virus targeting of human DAOY medulloblastoma, Peyton Society 80th Anniversary Meeting, Minneapolis, MN 2017
  • Sipe CJ, Shiao ML, and Low WC, Characterization of the Zika virus as an oncolytic virus in murine GL261 gliomas, Peyton Society 80th Anniversary Meeting, Minneapolis, MN 2017
  • Voth J, Miller ZD, Danczyk G, Low WC, and Parr AM, Porcine to porcine blastocyst complementation to generate oligodendrocytes, Peyton Society 80th Anniversary Meeting, Minneapolis, MN 2017
  • Crane A, Swaminathan P, Hewitt H, Xiao F, Savanur V, Voth J, Schultz Z, Carlson D, Fahrenkrug S, Dutton J, and Low WC, Use of blastocyst complementation in identifying novel source of tissue for craniofacial and neural regenerative therapies, Federation of European Neuroscience Society Annual Meeting, Copenhagen, Denmark, 2016

Presentations (Selected)

  • 13th International Conference on Alzheimer’s and Parkinson’s, “Towards the Generation of Nigral Dopamine Neurons in Gene Edited Animals via Stem Cell Complementation for Treating Parkinson’s Disease,” Vienna, Austria, 2017
  • 13th International Neural Transplantation and Repair Symposium, “Characterization of Chimeric Human-Porcine Blastocysts and PITX3 Knockout Swine for Generating Authentic Human Cells in the Pig,” Beijing, China, 2015
  • Frontiers in Biomedical Research Symposium, “Stem Cells for Neural Repair,” Karolinska Institute, Stockholm, Sweden, 2010
  • International Meeting of the Society for NeuroImmune Pharmacology, “State of the Art in Neural Stem Cell Biology,” Keynote Speaker, Wuhan, China, 2009
  • International Symposium on Stem Cells and Transplantation, “Pluripotency and Neural Induction of Mesenchymal Stem Cells Derived from Adult Bone Marrow,” Nantes, France, 2003

Invited Oral Presentations (Selected)

  • Cambridge HealthTech Institute, “Gene Editing for Generating Exogenic Organs and Cells,” Boston, MA 2016
  • American Society for Neural Therapy and Repair, Workshop on Techniques for NeuroRepair, “Generating Authentic Neural Cells for Cellular Replacement and Repair,” Clearwater, FL 2016
  • National Institutes of Health, Workshop on Animals Containing Human Cells, “Characterization of Human-Porcine Blastocysts and Fetuses,” Bethesda, MD, 2015
  • Iowa State University, "Neural Induction of Bone Marrow-Derived Stem Cells," Ames, Iowa, 2003
  • University of South Florida, “Neural Induction of Multipotent Adult Progenitor Cells (MAPCs) from Bone Marrow,” Tampa, Florida, 2003

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