Wei Chen, PhD

Professor, Radiology and Biomedical Engineering, Department of Radiology

Wei Chen

Contact Info

chenx075@umn.edu

Office Phone 612-625-8814

Fax 612-626-2004

Office Address:
Radiology-CMRR
102 CMRR
2021 6th St SE
Minneapolis, MN 55455

Mailing Address:
Magnetic Resonance Res, Ctr Fr
MMC 292 Mayo
8292B (Campus Delivery Code)
420 Delaware St SE
Minneapolis, MN 55455

Professor, Radiology and Biomedical Engineering, Department of Radiology


PhD, Washington University (Physical Chemistry)

MA, Washington University (Physical Chemistry)

BS, Fudan University (Physical Chemistry)

Summary

Dr. Wei Chen is a Professor in the Departments of Radiology and Biomedical Engineering at the University of Minnesota. He received his B.S. degree in physical chemistry at Fudan University in Shanghai, China. In 1985, he joined Professor Ackerman's lab as a graduate student at Washington University in St. Louis and received his Ph.D. in 1990. He spent three years as a postdoctoral fellow and research associate in Professor Shulman's lab at Yale University Medical School. In 1994, he joined the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota and became a full professor in 2002. His research focuses on development of magnetic resonance imaging (MRI)/spectroscopy (MRS) methodologies and technologies for noninvasively studying cellular metabolism, bioenergetics, function and dysfunction of the brain and other organs. He has been a principal investigator for a large number of NIH RO1 grants, served as grant reviewer for many funding organizations and editorial boards for imaging journals.

Research

Research Summary/Interests

  • To quantitatively determine the dynamic relationships of metabolic and homodynamic changes in response to neuronal activity in the human brain using functional MRI (fMRI) and functional MRS (fMRS).
  • To explore and improve the capability of fMRI for mapping functional organizations and sub-organizations covering the entire brain, consequently, to achieve functional mapping neural networks in the human brain.
  • To develop and establish the 17O magnetic resonance spectroscopic (MRS) imaging methodology at ultra-high magnetic fields for imaging regional cerebral oxygen consumption rate (CMRO2) in animals and humans non-invasively.
  • To establish and improve the dynamic fMRI approach for probing fast neuronal interactions during brain activation.
  • To develop robust and efficient high-field RF coils using the approach based on the microstrip transmission line resonator.

Current Ongoing Research Projects

  1. To quantitatively determine the dynamic relationships of metabolic and homodynamic changes in response to neuronal activity in the human brain using functional MRI (fMRI) and functional MRS (fMRS).
  2. To explore and improve the capability of fMRI for mapping functional organizations and sub-organizations covering the entire brain, consequently, to achieve functional mapping neural networks in the human brain.
  3. To develop and establish the 17O magnetic resonance spectroscopic (MRS) imaging methodology at high/ultrahigh magnetic fields for imaging regional cerebral oxygen consumption rate (CMRO2) in animals and humans non-invasively.
  4. To develop in vivo 31P MRS approaches for studying high-energy phosphate metabolism, in particular, related to ATP production and utilization for supporting brain function.
  5. To establish and improve the dynamic fMRI approach for probing fast neuronal interactions during brain activation.
  6. To study brain at both normal and pathological conditions.

Publications

  • Lu M, Zhu XH, Zhang Y, Chen W. Intracellular redox state revealed by in vivo 31P MRS measurement of NAD+ and NADH contents in brains. Magn Reson Med 2014;71:1959-1972.
  • Zhu XH, Qiao H, Du F, Xiong Q, Liu X, Zhang X, Ugurbil K, Chen W. Quantitative imaging of energy expenditure in human brain. Neuroimage 2012;60:2107-2117.
  • Liu X, Zhu XH, Zhang Y, Chen W. Neural origin of spontaneous hemodynamic fluctuations in rats under burst-suppression anesthesia condition. Cereb Cortex 2011;21:374-384.
  • Zhang N, Zhu XH, Zhang Y, Park JK, Chen W. High-resolution fMRI mapping of ocular dominance layers in cat lateral geniculate nucleus. Neuroimage 2010;50:1456-1463.
  • Zhu XH, Zhang N, Zhang Y, Ugurbil K, Chen W. New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brain. J Cereb Blood Flow Metab 2009;29:10-18.
  • Du F, Zhu XH, Zhang Y, Friedman M, Zhang N, Ugurbil K, Chen W. Tightly coupled brain activity and cerebral ATP metabolic rate. Proc Natl Acad Sci USA 2008;105:6409-6414.
  • Zhu XH, Zhang N, Zhang Y, Zhang X, Ugurbil K, Chen W. In vivo 17O NMR approaches for brain study at high field. NMR Biomed 2005; 18: 83-103.
  • Zhang NY, Zhu XH, Lei H, Ugurbil K, Chen W. Simplified Methods for Calculating Cerebral Metabolic Rate of Oxygen Based On 17O MRS Imaging Measurement Following A Short 17O2 Inhalation. J Cereb Blood Flow Metab 2004; 24: 840-848.
  • Lei H, Ugurbil K, Chen W. Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy. Proc Natl Acad Sci USA 2003;100:14409-14414.
  • Zhu XH, Zhang Y, Tian RX, Lei H, Zhang N, Zhang X, Merkle H, Ugurbil K, Chen W. Development of 17O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field. Proc Natl Acad Sci USA 2002;99:13194-13199.
  • Ogawa S, Lee TM, Stepnoski R, Chen W, Zhu XH, Ugurbil K. An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds. Proc Natl Acad Sci USA 2000;97:11026-11031.
  • Chen W, Zhu XH, Thulborn KR, Ugurbil K. Retinotopic mapping of lateral geniculate nucleus in humans using functional magnetic resonance imaging. Proc Natl Acad Sci USA 1999;96:2430-2434.
  • Chen W, Novotny EJ, Zhu XH, Rothman DL, Shulman RG. Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proc Natl Acad Sci USA 1993;90:9896-9900.