PhD Level Minor
The minor in Stem Cell Biology is available to students in relevant Ph.D. programs such as MCDB&G, MICaB, Neuroscience, Pharmacology, Bioengineering with an interest in stem cell biology. In addition to the major requirement appropriate to the specific program, the Stem Cell Biology Minor will require:
- minimum of 12 credits from designated courses
- 3.0 GPA minimum.
- A main research project of the Ph.D. degree must be done in the lab of a faculty member of the Stem Cell Biology graduate program.
Required Courses (10 credits)
The course provides beginning graduate students with an overview of stem cell biology. Topics include: embryonic stem cells; biochemistry of pluripotency; neural and hematopoietic stem cells; cell production and renewal in muscle, kidney, pancreas, and heart; limb regeneration. Ethical and legal issues raised by embryonic stem cell work; clinical cell therapy in selected areas. Students will be expected to read and present primary research literature.
3.0 credits; Prerequsites: (4034 or 8121 or BIOC 8002), (4161 or 8161) or instructor approval; Fall semester, every year
Structure and organization of genes. Replication. Transcription. Epigenetic modification of chromatin. Genome editing. Deep sequencing.Cellular adhesion mechanisms.
2.0 credits; Prerequisties: BMBB or MCDB concurrent registration is required (or allowed) in G grad student or instr consent; First half of fall semester, every year
Translation. RNA editing. Epigenetics and long non-coding RNA. MicroRNAs and RNA interference. Pre-mRNA processing.
2.0 credits; Prerequisties: BMBB or MCDB concurrent registration is required (or allowed) in G grad student or instr consent; Second half of fall semester, every year
Current concepts of and experimental approaches taken to understand basic mechanisms of development. Model organisms. Embryology, cell fate determination, differentiation, pattern formation, polarity, cell migration, and cell interactions. Analysis of original research articles..
3.0 credits; Prerequisites: (4034 or 8121 or BioC 800), (8131 or Biol 4003), Biol 4004 or instructor approval; Spring semester, every year
Elective Courses (minimum of 2 credits)
Ethics of scientific investigation from viewpoint of western scientific enterprise. Relationship between science, culture, and public policies. Careers in molecular/cellular biology. Nontraditional career tracks. Invited speakers, case studies, small-group discussions, lectures.
1.0 credit (max 2.0 credits); Prerequisites: Grad student in (BMBB or MCDB&G); S-N or Aud, Fall and spring semester, every year
BTHX 8000: Advanced Topics in Bioethics: Ethics, Policy and Law in Controversial Science
There is a history of policy making in the US.for the oversight of controversial science, whether it is basic laboratory research (eg, recombinant DNA, human embryonic stem cell research), research involving humans (eg, gene transfer research) or clinical medicine (eg, organ donation and transplantation). This course will examine some of that history, and the ethics, law and policy that have been applied in crafting policy in these areas. The goal is to assess what has been learned over the history and how those lessons can be applied in new and evolving areas of controversial science.
3.0 credits; Prerequisite: 4xxx or 5xxx ethics course or instructor approval; Fall semester
Fundamentals of wound healing and tissue repair; characterization of cell-matrix interactions; case study of engineered tissues, including skin, bone marrow, liver, vessel, and cartilage; regulation of biomaterials and engineered tissues.
3.0 credits; Prerequites: IT upper div or grad student or med student or instructor approval; Fall and spring semester, every year
Engineering approaches to cell-related phenomena important to cell/tissue engineering. Receptor/ligand binding. Trafficking/signaling processes. Applications to cell proliferation, adhesion, and motility. Cell-matrix interactions.
3.0 credits; Prerequisite: (2501 or 5501), CSCI 1107, (Math 2243 or Math 2373), IT upper div or grad student or instructor approval; Fall semester, Spring semester, offered periodically
Current gene transfer technology. Applications of genetic modifications in animals, particularly transgenic animals and human gene therapy.
2.0 credits; Prerequite: instructor approval; A-F or Aud, Spring semester, every year
Literature-based course covering modern genetic analysis, including mutant screens, characterization of multiple alleles, gene mapping and cloning, genome sequencing, intergenic interactions, transposable elements, genetic mosaics, and molecular mechanisms of recombination.
3.0 credits; Prerequisites: 3022 or Biol 4003, BioC 3021 or BioC 4331 or instructor approval; Fall semester, every year
Structure, function, and biochemistry of cellular organelles. Cellular interactions in eukaryotes. Emphasizes membranes, secretion, trafficking, cytoskeleton, cell motility, nucleus, cell cycle, apoptosis, cell signaling, and signal transduction mechanisms.
3.0 credits; Prerequisites: (4034 or 8121 or BioC 8002), Biol 4004 or BMBB or MCDB&G grad student, instructor approval; Fall semester, every year
Lymphocyte activation, signal transduction in lymphocytes, antigen receptor genetics, antigen presentation, lymphoid anatomy, adaptive immune responses to microbes, immunodeficiency, immunopathology, cytokines, transplantation, autoimmunity.
4.0 credits; Prerequisites: Upper level undergrad immunology course or instructor approval; Spring semester, every year
Fundamental concepts in cellular, molecular, and genetic basis of disease. Molecular basis of inflammation and cancer metastasis. Genetic basis for inherited disorders and gene therapy. Molecular mechanisms of pathogenesis.
4.0 credits; Prerequisites: One undergrad or grad course each in (biochemistry, cell biology) or instructor approval; A-F or Aud, Spring semester, every year
How neuronal types develop. Emphasizes general mechanisms. Experimental data demonstrating mechanisms.
3.0 credits; Prerequisites: Neuroscience grad student or instructor approval; A-F or Aud, Spring, every year
Basic principles of Pharmacology. Focuses on molecular mechanisms of drug action.
3.0 credits; Prerequisite: Grad student or instructor approval; A-F or Aud, Fall semester, every year
NOTE: Students may not use credits offered in their major field to satisfy minor requirements.