If you have questions about stem cell research, questions will be referred directly to the Director of the Stem Cell Institute or to the scientist/physician with the most applicable knowledge and research. Please contact Caroline Marin at 612-624-5680 to set up an interview.
In the news
Brenda Ogle, PhD, a Stem Cell Institute faculty member and associate professor of biomedical engineering, is part of a team that has created a revolutionary 3D-bioprinted patch that can help heal scarred heart tissue after a heart attack. The team is comprised of researchers from UMN, University of Wisconsin-Madison and the University of Alabama-Birmingham. Researchers used laser-based 3D-bioprinting techniques to incorporate stem cells derived from adult human heart cells on a matrix that began to grow and beat synchronously in a dish in the lab. Read more about the study published recently in Circulation Research.
On April 10, Regenerative Medicine Minnesota (RMM) announced awards. Congratulations to the following SCI Faculty
Research Grant Awards
- Karen Echeverri, PhD - Spinal Cord Regeneration: Translating from Salamanders to Enhance Regenerative Repair after Injury in Mammals
- Mark J. Osborn, PhD - Natural Killer Cell Chimeric Antigen Receptor Therapy
- Jop van Berlo, PhD - Identification of Novel Regulators of Heart Regeneration
Educational Grant Award
Troy Lund, MD, PhD - Medical Student Summer Research Program in Regenerative Medicine - Pre-T35
Biobusiness Grant Awards
- James Dutton, PhD - Critical infrastructure to support new stem cell-derived treatments for patients with age-related macular degeneration in Minnesota
- Walter Low, PhD - Production of Dopamine Neurons – A Cellular Product for Treating Parkinson’s
The University of Minnesota is joining the Advanced Regenerative Manufacturing Institute (ARMI), a consortium of nearly 100 organizations spanning industry, government, academia and the non-profit sector. The Institute is set to receive nearly $300 million in public-private investment to develop scalable manufacturing processes for engineered tissues and organs. The University will be developing training curricula for 2- and 4-year colleges that will educate educate students about Tissue and Organ Biofabrication, 3D Bioprinting and Regenerative Medicine.
Stem Cell Institute faculty member, Angela Panoskaltsis-Mortari, PhD, led the ARMI submission process for the Midwest region. She is excited about "being a part of an effort that could benefit patients and our economy."
When scientists can determine what type of cell a stem cell will become, they can better manipulate cells for stem cell therapy. Scientists at Rutgers and other universities have created a new way to identify the state and fate of stem cells earlier than previously possible. The approach, called EDICTS (Epi-mark Descriptor Imaging of Cell Transitional States), involves labeling epigenetic modifications and then imaging the cells with super resolution to see the precise location of the marks.
The regenerative biology team at the Morgridge Institute for Research, led by stem cell pioneer and University of Wisconsin-Madison Professor James Thomson, is studying whether stem cell differentiation rates can be accelerated in the lab and made available to patients faster. While the study published in the February issue ofScience Direct suggests that cellular timing is a stubborn process, the Thomson lab is exploring a variety of follow-up studies on potential factors that could help cells alter their pace, Barry says.
The research team of Dr. Scott Kaufmann, leader of Mayo’s Anticancer Drug Action Laboratory, and Daniel Harki, a U of M assistant professor of medicinal chemistry, Stem Cell Institute member, and director of the Harki Lab, in January saw their patent application for a method of “assessing enzyme-nucleic acid complexes” published by the U.S. Patent and Trademark Office, with Mayo and the U of M named as the assignees.
Dr. Mehmet Oz investigates and uncovers the dangers of unregulated stem cell clinics, citing absence of scientific support for treatment. Dr. Oz features a series of segments on his daytime television program that expose the scams that take advantage of the most vulnerable.
Jaime Modiano, SCI and UMN College of Veterinary Medicine Faculty member and colleague, Antonella Borgatti, developed and tested a cancer drug that they believe could someday help patients live longer and with fewer side effects. After leading a study treating dogs with HSA Sarcoma, a fast-spreading incurable cancer, Dr. Modiano said "We just never expected it was going to work as well as it did."