Stem Cell Frequently Asked Questions

submenu

The Promise of Stem Cells: Stem cells can develop into different cell types. They may offer a renewable source of replacement cells to treat diseases, conditions, and disabilities.

Source: http://stemcells.nih.gov/Pages/Default.aspx

What does the Stem Cell Institute do?

What does the Stem Cell Institute do?

The University of Minnesota Stem Cell Institute (SCI), the first such institute in the United States, studies the basic biology of how stem cells work. The SCI faculty works in collaboration with many other areas in the University to lay the foundation for safe and effective treatments using stem cells. The SCI performs research and does not treat patients directly.

What are stem cells?

What are stem cells?

Cells are categorized as “stem” cells when they have the ability, as they divide and reproduce, to generate cells of several different types. The Stem Cell Institute works with many different types of stem cells. Stem cells can be “pluripotent” (able to generate any type of cell found in the body), “multipotent” (able to generate a limited number of different cell types), or oligopotent (able to generate two or more cell types within a specific tissue).

What types of stem cells are studied?

What types of stem cells are studied?

2012 Nobel Prize

Induced pluripotent stem cells (iPSCs) are created by taking adult cells and reprogramming them to express genes that are active in stem cells until they again have the potential to develop into different types of cells. In this way, iPSCs made from adult skin cells could be used not only to repair the skin, but to repair a damaged heart muscle or liver. This technology is extensively in use at the University of Minnesota and is thought to be a highly promising option for many different patient therapies. An important potential advantage of using a patient’s own cells for treatment is that bodies do not reject their own cells. This reduces the risk and increases the possible effectiveness of using these cells.

Adult stem cells, found in the blood, bone marrow, muscle, and organs (for example, the brain, liver, and skin), are multipotent and part of the body’s system to maintain and repair itself. Their ability to generate different cell types is usually limited to the type of tissue in which they are found.

Hematopoietic stem cells (blood-forming, multipotent) are present in bone marrow, circulating blood, and umbilical cord blood. These cells have been transplanted for over 40 years in order to help patients who suffer from devastating bone marrow and blood diseases (such as severe aplastic anemia and types of leukemia) and some genetic conditions (such as Fanconi anemia). These cells are donated for a specific patient’s use by people who undergo a minor surgical procedure to remove them from the bone marrow or apheresis (a system that filters selected cells from the circulating blood). Umbilical cord blood cells are donated shortly after birth and removed from tissue that is otherwise discarded.

Embryonic stem cells are truly pluripotent and as such, offer unique windows into the incredibly complex systems of cell and body development. Both animal and human embryonic stem cells are studied. All research on human cells at the University of Minnesota is performed using cell lines that were generated from fertilized, frozen eggs created for in-vitro fertilization and donated by people who wanted the eggs to support medical research rather than be discarded. These “cell lines” were created a number of years ago and are limited and regulated by the government. No state or US government funds are used for this research; it is entirely funded by private donations. We understand that human embryonic research is a controversial and sensitive matter and welcome civil dialogue about the legal, ethical, and moral issues of this research. All new research proposals using human embryonic cell lines must be approved by the human Embryonic Stem Cell and human embryo Research Oversight (ESCRO) committee. This committee has been set up in accordance with National Research Council guidelines to ensure that proposed research meets high standards for scientific merit and ethical justification before it can begin.

What medical conditions may be treated with stem cell therapy?

What medical conditions may be treated with stem cell therapy?

Some examples are listed below. For an outstanding resource on where research stands now, please see the website www.closerlookatstemcells.org

  • Brain and spinal cord injury
  • Diabetes
  • Heart disease
  • Retinal disorders
  • Inherited diseases
  • Cancer

How do I find out about the most up-to-date research?

How do I find out about the most up-to-date research?

If you are or know someone who is affected by a condition that might be treatable with stem cell therapy, you can use the resources below to stay up-to-date on research:

Find clinical trial information

Help fund research

You can support stem cell research on a specific disease or condition.

Make a donation

Have more questions?

Please send your questions to the University of Minnesota Stem Cell Institute. We will consider adding your questions to our website.

Email: SCI-admin@umn.edu
Provide website feedback

Media requests

For questions about stem cell research or to speak with an expert on this topic please contact Caroline Marin.

Media Contact:
Caroline Marin
612-624-5680
cmarin@umn.edu