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We bring together talent and expertise from across the University of Minnesota to use stem cell biology to advance regenerative medicine therapies for devastating disorders and to provide education and training for the stem cell scientists of tomorrow.

Welcome

 

 

Our Research

Our Education Programs

The bioscience and medical industries and academic research programs need intelligent, engaged, well-trained talent to fill jobs in the rapidly expanding field of regenerative medicine. The Stem Cell Institute prepares students who are ready to meet this need and who are eager to move the next generation of research forward. Learn more about our graduate programs:

In the News

February 15, 2017

Jaime ModianoJaime Modiano, SCI and UMN College of Veterinary Medicine Faculty member and colleague, Antonella Borgatti, developed and tested a cancer drug that they believe could someday help patients live longer and with fewer side effects. After leading a study treating dogs with HSA Sarcoma, a fast-spreading incurable cancer, Dr. Modiano said "We just never expected it was going to work as well as it did." 

February 1, 2017

James Dutton
 
 
 
SCI faculty member, James Dutton, has been working with researchers from the University of Wisconsin-Madison who developed a library of artificial transcription factors (ATF's). The library consists of many millions of combinations of small DNA binding protein sequences combined with transcription activation domains. The complexity of the library allows unbiased activation of gene expression at any locus.  Using this library to screen for key regulators of the pluripotency network, they discovered three combinations of ATF's capable of inducing pluripotency without exogenous expression of Oct4Dr Dutton is now applying this technology to discover new ways to reprogram cells to produce insulin secreting cells to treat diabetes.  Read "Reprogramming cell fate with a genome-scale library of artificial transcription factors" here.
 
December 22, 2016

University of MinnesotaA blood washing device invented by IEM Executive Committee Member Dr. Allison Hubel, Professor of Mechanical Engineering, and Director of the IEM-affiliated Biopreservation Core Resource (BioCoR), was featured by Twin Cities Business. The automated system cleanses from thawed blood glycerol preservatives, which are added to blood prior to its freezing for storage, and it does so more efficiently and safely than does a centrifuge, which has been the standard type of equipment used for this process and which requires more time and labor to use and results in high cell losses. Dr. Hubel's device could ultimately help to make large strategic reserves available from blood produced from stem cells, during emergencies when insufficient quantities of donated blood are available - something which is not as possible with centrifuges. The device took a big step toward this future with a $223,000 Phase I NIH SBIR grant awarded in September to the start-up company seeking to commercialize it, Headwaters Innovation Inc., led by a successful local entrepreneur.

 

December 22, 2016

IEM members Drs. Richard W. Bianco, Associate Professor of Surgery and Program Director of Experimental Surgical Services, and Brenda M. Ogle, Associate Professor of Biomedical Engineering have been elected to the 2017 Class of American Institute for Medical and Biological Engineering (AIMBE) Fellows. Drs. Bianco and Ogle will join the AIMBE College of Fellows, which consists of approximately "1,500 individuals who are the outstanding bioengineers in academia, industry and government. These leaders in the field have distinguished themselves through their contributions in research, industrial practice and/or education." Each will be inducted on March 20th at AIMBE's Annual Even in Washington, D.C.

Weekly Research Conference

Meets weekly in Room 1-110
McGuire Translational Research Facility (MTRF, next to Lion's Research Building)
[map] [shuttle schedule]

Wednesday, February 22, 2017 - 4:00pm

The role of o-linked n-acetylglucosamine signaling in pancreatic islet development and function

Emilyn Alejandro

Emilyn Alejandro, PhD
Assistant Professor, Department of Integrative Biology and Physiology
University of Minnesota

Wednesday, March 1, 2017 - 4:00pm

Translational control of skeletal muscle stem cells

Colin Crist

Colin Crist, PhD
Assistant Professor
Department of Human Genetics
McGill University
Montreal, Quebec, Canada

Wednesday, March 8, 2017 - 4:00pm

Cell-based therapies for Parkinson's Disease

Marina Emborg

Marina Emborg, Md/PhD
Associate Professor, Medical Physics
Stem Cell and Regenerative Medicine
Wisconsin Institutes for Medical Research
Madison, WI