We bring together talent and expertise from across the University of Minnesota to use stem cell biology to advance regenerative medicine therapies for devastating disorders and to provide education and training for the stem cell scientists of tomorrow.


Our Research

We depend on the variety of knowledge and expertise from faculty and departments across the University and beyond to pursue the collaborative goal of using stem cell technology to change the practice of regenerative medicine.

SCI scientists are making progress in finding treatments for spine and brain injury, heart damage, vision loss, diabetes, genetic disorders, cancer, and the need for organ and skin replacement. Learn more about:

Our Education Programs

The bioscience and medical industries and academic research programs need intelligent, engaged, well-trained talent to fill jobs in the rapidly expanding field of regenerative medicine. The Stem Cell Institute prepares students who are ready to meet this need and who are eager to move the next generation of research forward. Learn more about our graduate programs:

In the News

Reuben Harris photo
July 11, 2017

Congratulations to Reuben Harris, a member of the Stem Cell Institute and professor in the Department of Biochemistry, Molecular Biology, and Biophysics, who was recently recognized as a Distinguished McKnight University Professor.  The Distinguished McKnight University Professorship program recognizes outstanding faculty members who have recently achieved full professor status. Recipients hold the title “Distinguished McKnight University Professor” for as long as they remain employed at the University of Minnesota.

Tim O'Brien photo
May 31, 2017

Dr. Timothy O'Brien, UMN professor and Stem Cell Institute member, recently commented on a product, Cell-Mate 3D, that is produced in Two Harbors, MN by BRTI.  He described his work growing "cerebral organoids, not just brain cells, as has been done before, but fully formed, albeit microscopic, brain structures" in this relatively new three-dimensional medium rather than the traditional flat, hard bottom of a petri dish."  "This is potentially really important because they could be used for development of drugs for neurological problems — to check for toxic effects of drugs," said the University of Minnesota professor and member of the school's Stem Cell Institute. "What we're forming is much more like a real brain than what people have had access to before."  

Andrew Grande photo
May 23, 2017

Andrew Grande, M.D. of the UMN Medical School, Department of Neursurgery, and Stem Cell Institute faculty member discusses stroke awareness month on Sunday, May 14 on Roshini Rajkumar's WCCO radio show.  He shares information about strokes and educates the audience about what to do if someone thinks they are having a stroke.

May 16, 2017

blood cells

An exciting development in understanding how cancer works and potential ways of blocking it occurred recently in Dr. Rita Perlingeiro's laboratory. A new study in Blood shows that a glycoprotein on the cell surface called endoglin, also known as CD105, is a marker for the cancer stem cell in acute myeloid leukemia (AML) and acute B-lymphoblastic leukemia (B-ALL), suggesting it plays a role in its genesis.

After discovering this feature, lead researcher Rita Perlingeiro, PhD, professor in the University of Minnesota Medical School’s Department of Medicine and Stem Cell Institute Faculty member, then tested whether targeting endoglin would halt the progression of leukemia.  

Weekly Research Conference

Meets weekly in Room 1-110
McGuire Translational Research Facility (MTRF, next to Lion's Research Building)
[map] [shuttle schedule]

Wednesday, July 26, 2017 - 4:00pm

Critical role of an FK506-binding protein controlling myoblast differentiation

Mercedes Ruiz Estevez photo

Mercy Ruiz Estevez, PhD
Post Doc
Kikyo Lab

University of Minnesota

Wednesday, August 2, 2017 - 4:00pm

Mechanisms of squamous cell carcinoma development in patients with recessive dystrophic epidermolysis bullosa

Michael Pickett-Leonard photo

Michael Pickett-Leonard, PhD
Post Doc
Tolar Lab

University of Minnesota

Wednesday, August 9, 2017 - 4:00pm

Fanconi Anemia proteins in DNA repair and replication stress

Elizabeth Thompson photo

Elizabeth Thompson, MS
Graduate Student
Tolar Lab

University of Minnesota